We have introduced a change in the numbering of the nucleotides 3' of the
stop codon, following the most recent HGVS-recommendations.(last modified November 29, 2005)
We have introduced a change in the numbering of the nucleotides 3' of the
stop codon, following the most recent HGVS-recommendations.
Please note that the ancient dystrophin, lacking exon 78, encodes a protein that is has a different, longer C-terminal end. Consequently, variants up to nucleotide c.*86 affect the protein.
As of January 1, 2003 we use a new coding DNA Reference Sequence for nucleotide numbering to describe sequence changes in the DMD gene. This reference sequence is based on GenBank file NM_004006.1 (with one difference 12505G>A), containing the Dp427m isoform (muscle) of dystrophin. This new file replaces the old coding DNA reference sequence. The gene flanking and intronic sequences are derived from a range of GenBank files (see Genomic reference sequence of the DMD gene).
(upstream sequence)
exon 01 tcct -241
. . . . . .
ggcatcagttactgtgttgactcactcagtgttgggatcactcactttccccctacagga -181
. . . . . .
ctcagatctgggaggcaattaccttcggagaaaaacgaataggaaaaactgaagtgttac -121
. . . . . .
tttttttaaagctgctgaagtttgttggtttctcattgtttttaagcctactggagcaat -61
. . . . . .
aaagtttgaagaacttttaccaggttttttttatcgctgccttgatatacacttttcaaa -1
. . . | 2 . . .
ATGCTTTGGTGGGAAGAAGTAGAGGACTGTT | ATGAAAGAGAAGATGTTCAAAAGAAAACA 60
M L W W E E V E D C Y | E R E D V Q K K T 20
. . . | 3 . . .
TTCACAAAATGGGTAAATGCACAATTTTCTAAG | TTTGGGAAGCAGCATATTGAGAACCTC 120
F T K W V N A Q F S K | F G K Q H I E N L 40
. . . . . .
TTCAGTGACCTACAGGATGGGAGGCGCCTCCTAGACCTCCTCGAAGGCCTGACAGGGCAA 180
F S D L Q D G R R L L D L L E G L T G Q 60
| 4 . . . . . .
AAACTG | CCAAAAGAAAAAGGATCCACAAGAGTTCATGCCCTGAACAATGTCAACAAGGCA 240
K L | P K E K G S T R V H A L N N V N K A 80
. . | 5 . . . .
CTGCGGGTTTTGCAGAACAATAAT | GTTGATTTAGTGAATATTGGAAGTACTGACATCGTA 300
L R V L Q N N N | V D L V N I G S T D I V 100
. . . . . | 6 .
GATGGAAATCATAAACTGACTCTTGGTTTGATTTGGAATATAATCCTCCACTGGCAG | GTC 360
D G N H K L T L G L I W N I I L H W Q | V 120
. . . . . .
AAAAATGTAATGAAAAATATCATGGCTGGATTGCAACAAACCAACAGTGAAAAGATTCTC 420
K N V M K N I M A G L Q Q T N S E K I L 140
. . . . . .
CTGAGCTGGGTCCGACAATCAACTCGTAATTATCCACAGGTTAATGTAATCAACTTCACC 480
L S W V R Q S T R N Y P Q V N V I N F T 160
. . . . . | 7 .
ACCAGCTGGTCTGATGGCCTGGCTTTGAATGCTCTCATCCATAGTCATAG | GCCAGACCTA 540
T S W S D G L A L N A L I H S H R | P D L 180
. . . . . .
TTTGACTGGAATAGTGTGGTTTGCCAGCAGTCAGCCACACAACGACTGGAACATGCATTC 600
F D W N S V V C Q Q S A T Q R L E H A F 200
. . . . | 8 .
AACATCGCCAGATATCAATTAGGCATAGAGAAACTACTCGATCCTGAAG | ATGTTGATACC 660
N I A R Y Q L G I E K L L D P E D | V D T 220
. . . . . .
ACCTATCCAGATAAGAAGTCCATCTTAATGTACATCACATCACTCTTCCAAGTTTTGCCT 720
T Y P D K K S I L M Y I T S L F Q V L P 240
. . . . . .
CAACAAGTGAGCATTGAAGCCATCCAGGAAGTGGAAATGTTGCCAAGGCCACCTAAAGTG 780
Q Q V S I E A I Q E V E M L P R P P K V 260
. . . . . | 9 .
ACTAAAGAAGAACATTTTCAGTTACATCATCAAATGCACTATTCTCAACAG | ATCACGGTC 840
T K E E H F Q L H H Q M H Y S Q Q | I T V 280
. . . . . .
AGTCTAGCACAGGGATATGAGAGAACTTCTTCCCCTAAGCCTCGATTCAAGAGCTATGCC 900
S L A Q G Y E R T S S P K P R F K S Y A 300
. . . . . .
TACACACAGGCTGCTTATGTCACCACCTCTGACCCTACACGGAGCCCATTTCCTTCACAG 960
Y T Q A A Y V T T S D P T R S P F P S Q 320
| 10 . . . . . .
| CATTTGGAAGCTCCTGAAGACAAGTCATTTGGCAGTTCATTGATGGAGAGTGAAGTAAAC 1020
| H L E A P E D K S F G S S L M E S E V N 340
. . . . . .
CTGGACCGTTATCAAACAGCTTTAGAAGAAGTATTATCGTGGCTTCTTTCTGCTGAGGAC 1080
L D R Y Q T A L E E V L S W L L S A E D 360
. . . . . .
ACATTGCAAGCACAAGGAGAGATTTCTAATGATGTGGAAGTGGTGAAAGACCAGTTTCAT 1140
T L Q A Q G E I S N D V E V V K D Q F H 380
| 11 . . . . .
ACTCATGAG | GGGTACATGATGGATTTGACAGCCCATCAGGGCCGGGTTGGTAATATTCTA 1200
T H E | G Y M M D L T A H Q G R V G N I L 400
. . . . . .
CAATTGGGAAGTAAGCTGATTGGAACAGGAAAATTATCAGAAGATGAAGAAACTGAAGTA 1260
Q L G S K L I G T G K L S E D E E T E V 420
. . . . . .
CAAGAGCAGATGAATCTCCTAAATTCAAGATGGGAATGCCTCAGGGTAGCTAGCATGGAA 1320
Q E Q M N L L N S R W E C L R V A S M E 440
. | 12 . . . . .
AAACAAAGCAA | TTTACATAGAGTTTTAATGGATCTCCAGAATCAGAAACTGAAAGAGTTG 1380
K Q S N | L H R V L M D L Q N Q K L K E L 460
. . . . . .
AATGACTGGCTAACAAAAACAGAAGAAAGAACAAGGAAAATGGAGGAAGAGCCTCTTGGA 1440
N D W L T K T E E R T R K M E E E P L G 480
. . . . | 13 . .
CCTGATCTTGAAGACCTAAAACGCCAAGTACAACAACATAAG | GTGCTTCAAGAAGATCTA 1500
P D L E D L K R Q V Q Q H K | V L Q E D L 500
. . . . . .
GAACAAGAACAAGTCAGGGTCAATTCTCTCACTCACATGGTGGTGGTAGTTGATGAATCT 1560
E Q E Q V R V N S L T H M V V V V D E S 520
. . . . | 14 . .
AGTGGAGATCACGCAACTGCTGCTTTGGAAGAACAACTTAAG | GTATTGGGAGATCGATGG 1620
S G D H A T A A L E E Q L K | V L G D R W 540
. . . . . .
GCAAACATCTGTAGATGGACAGAAGACCGCTGGGTTCTTTTACAAGACATCCTTCTCAAA 1680
A N I C R W T E D R W V L L Q D I L L K 560
. . | 15 . . . .
TGGCAACGTCTTACTGAAGAACAG | TGCCTTTTTAGTGCATGGCTTTCAGAAAAAGAAGAT 1740
W Q R L T E E Q | C L F S A W L S E K E D 580
. . . . . .
GCAGTGAACAAGATTCACACAACTGGCTTTAAAGATCAAAATGAAATGTTATCAAGTCTT 1800
A V N K I H T T G F K D Q N E M L S S L 600
. | 16 . . . . .
CAAAAACTGGCC | GTTTTAAAAGCGGATCTAGAAAAGAAAAAGCAATCCATGGGCAAACTG 1860
Q K L A | V L K A D L E K K K Q S M G K L 620
. . . . . .
TATTCACTCAAACAAGATCTTCTTTCAACACTGAAGAATAAGTCAGTGACCCAGAAGACG 1920
Y S L K Q D L L S T L K N K S V T Q K T 640
. . . . . .
GAAGCATGGCTGGATAACTTTGCCCGGTGTTGGGATAATTTAGTCCAAAAACTTGAAAAG 1980
E A W L D N F A R C W D N L V Q K L E K 660
. | 17 . . . . .
AGTACAGCACAG | ATTTCACAGGCTGTCACCACCACTCAGCCATCACTAACACAGACAACT 2040
S T A Q | I S Q A V T T T Q P S L T Q T T 680
. . . . . .
GTAATGGAAACAGTAACTACGGTGACCACAAGGGAACAGATCCTGGTAAAGCATGCTCAA 2100
V M E T V T T V T T R E Q I L V K H A Q 700
. . . . . .
GAGGAACTTCCACCACCACCTCCCCAAAAGAAGAGGCAGATTACTGTGGATTCTGAAATT 2160
E E L P P P P P Q K K R Q I T V D S E I 720
| 18 . . . . .
AGGAAAAG | GTTGGATGTTGATATAACTGAACTTCACAGCTGGATTACTCGCTCAGAAGCT 2220
R K R | L D V D I T E L H S W I T R S E A 740
. . . . . .
GTGTTGCAGAGTCCTGAATTTGCAATCTTTCGGAAGGAAGGCAACTTCTCAGACTTAAAA 2280
V L Q S P E F A I F R K E G N F S D L K 760
. | 19 . . . . .
GAAAAAGTCAAT | GCCATAGAGCGAGAAAAAGCTGAGAAGTTCAGAAAACTGCAAGATGCC 2340
E K V N | A I E R E K A E K F R K L Q D A 780
. . . . | 20 . .
AGCAGATCAGCTCAGGCCCTGGTGGAACAGATGGTGAATG | AGGGTGTTAATGCAGATAGC 2400
S R S A Q A L V E Q M V N E | G V N A D S 800
. . . . . .
ATCAAACAAGCCTCAGAACAACTGAACAGCCGGTGGATCGAATTCTGCCAGTTGCTAAGT 2460
I K Q A S E Q L N S R W I E F C Q L L S 820
. . . . . .
GAGAGACTTAACTGGCTGGAGTATCAGAACAACATCATCGCTTTCTATAATCAGCTACAA 2520
E R L N W L E Y Q N N I I A F Y N Q L Q 840
. . . . . .
CAATTGGAGCAGATGACAACTACTGCTGAAAACTGGTTGAAAATCCAACCCACCACCCCA 2580
Q L E Q M T T T A E N W L K I Q P T T P 860
. . . . | 21 . .
TCAGAGCCAACAGCAATTAAAAGTCAGTTAAAAATTTGTAAG | GATGAAGTCAACCGGCTA 2640
S E P T A I K S Q L K I C K | D E V N R L 880
. . . . . .
TCAGGTCTTCAACCTCAAATTGAACGATTAAAAATTCAAAGCATAGCCCTGAAAGAGAAA 2700
S G L Q P Q I E R L K I Q S I A L K E K 900
. . . . . .
GGACAAGGACCCATGTTCCTGGATGCAGACTTTGTGGCCTTTACAAATCATTTTAAGCAA 2760
G Q G P M F L D A D F V A F T N H F K Q 920
. . . . | 22 . .
GTCTTTTCTGATGTGCAGGCCAGAGAGAAAGAGCTACAGACAA | TTTTTGACACTTTGCCA 2820
V F S D V Q A R E K E L Q T I | F D T L P 940
. . . . . .
CCAATGCGCTATCAGGAGACCATGAGTGCCATCAGGACATGGGTCCAGCAGTCAGAAACC 2880
P M R Y Q E T M S A I R T W V Q Q S E T 960
. . . . . .
AAACTCTCCATACCTCAACTTAGTGTCACCGACTATGAAATCATGGAGCAGAGACTCGGG 2940
K L S I P Q L S V T D Y E I M E Q R L G 980
| 23 . . . . .
GAATTGCAG | GCTTTACAAAGTTCTCTGCAAGAGCAACAAAGTGGCCTATACTATCTCAGC 3000
E L Q | A L Q S S L Q E Q Q S G L Y Y L S 1000
. . . . . .
ACCACTGTGAAAGAGATGTCGAAGAAAGCGCCCTCTGAAATTAGCCGGAAATATCAATCA 3060
T T V K E M S K K A P S E I S R K Y Q S 1020
. . . . . .
GAATTTGAAGAAATTGAGGGACGCTGGAAGAAGCTCTCCTCCCAGCTGGTTGAGCATTGT 3120
E F E E I E G R W K K L S S Q L V E H C 1040
. . . . | 24 . .
CAAAAGCTAGAGGAGCAAATGAATAAACTCCGAAAAATTCAG | AATCACATACAAACCCTG 3180
Q K L E E Q M N K L R K I Q | N H I Q T L 1060
. . . . . .
AAGAAATGGATGGCTGAAGTTGATGTTTTTCTGAAGGAGGAATGGCCTGCCCTTGGGGAT 3240
K K W M A E V D V F L K E E W P A L G D 1080
. . . | 25 . . .
TCAGAAATTCTAAAAAAGCAGCTGAAACAGTGCAGA | CTTTTAGTCAGTGATATTCAGACA 3300
S E I L K K Q L K Q C R | L L V S D I Q T 1100
. . . . . .
ATTCAGCCCAGTCTAAACAGTGTCAATGAAGGTGGGCAGAAGATAAAGAATGAAGCAGAG 3360
I Q P S L N S V N E G G Q K I K N E A E 1120
. . . . . .
CCAGAGTTTGCTTCGAGACTTGAGACAGAACTCAAAGAACTTAACACTCAGTGGGATCAC 3420
P E F A S R L E T E L K E L N T Q W D H 1140
. | 26 . . . . .
ATGTGCCAACAG | GTCTATGCCAGAAAGGAGGCCTTGAAGGGAGGTTTGGAGAAAACTGTA 3480
M C Q Q | V Y A R K E A L K G G L E K T V 1160
. . . . . .
AGCCTCCAGAAAGATCTATCAGAGATGCACGAATGGATGACACAAGCTGAAGAAGAGTAT 3540
S L Q K D L S E M H E W M T Q A E E E Y 1180
. . . . . .
CTTGAGAGAGATTTTGAATATAAAACTCCAGATGAATTACAGAAAGCAGTTGAAGAGATG 3600
L E R D F E Y K T P D E L Q K A V E E M 1200
| 27 . . . . . .
AAG | AGAGCTAAAGAAGAGGCCCAACAAAAAGAAGCGAAAGTGAAACTCCTTACTGAGTCT 3660
K | R A K E E A Q Q K E A K V K L L T E S 1220
. . . . . .
GTAAATAGTGTCATAGCTCAAGCTCCACCTGTAGCACAAGAGGCCTTAAAAAAGGAACTT 3720
V N S V I A Q A P P V A Q E A L K K E L 1240
. . . . . .
GAAACTCTAACCACCAACTACCAGTGGCTCTGCACTAGGCTGAATGGGAAATGCAAGACT 3780
E T L T T N Y Q W L C T R L N G K C K T 1260
| 28 . . . . . .
TTGGAA | GAAGTTTGGGCATGTTGGCATGAGTTATTGTCATACTTGGAGAAAGCAAACAAG 3840
L E | E V W A C W H E L L S Y L E K A N K 1280
. . . . . .
TGGCTAAATGAAGTAGAATTTAAACTTAAAACCACTGAAAACATTCCTGGCGGAGCTGAG 3900
W L N E V E F K L K T T E N I P G G A E 1300
. . | 29 . . . .
GAAATCTCTGAGGTGCTAGAT | TCACTTGAAAATTTGATGCGACATTCAGAGGATAACCCA 3960
E I S E V L D | S L E N L M R H S E D N P 1320
. . . . . .
AATCAGATTCGCATATTGGCACAGACCCTAACAGATGGCGGAGTCATGGATGAGCTAATC 4020
N Q I R I L A Q T L T D G G V M D E L I 1340
. . . . . | 30 .
AATGAGGAACTTGAGACATTTAATTCTCGTTGGAGGGAACTACATGAAGAG | GCTGTAAGG 4080
N E E L E T F N S R W R E L H E E | A V R 1360
. . . . . .
AGGCAAAAGTTGCTTGAACAGAGCATCCAGTCTGCCCAGGAGACTGAAAAATCCTTACAC 4140
R Q K L L E Q S I Q S A Q E T E K S L H 1380
. . . . . .
TTAATCCAGGAGTCCCTCACATTCATTGACAAGCAGTTGGCAGCTTATATTGCAGACAAG 4200
L I Q E S L T F I D K Q L A A Y I A D K 1400
. . . | 31 . . .
GTGGACGCAGCTCAAATGCCTCAGGAAGCCCAG | AAAATCCAATCTGATTTGACAAGTCAT 4260
V D A A Q M P Q E A Q | K I Q S D L T S H 1420
. . . . . .
GAGATCAGTTTAGAAGAAATGAAGAAACATAATCAGGGGAAGGAGGCTGCCCAAAGAGTC 4320
E I S L E E M K K H N Q G K E A A Q R V 1440
. . | 32 . . . .
CTGTCTCAGATTGATGTTGCACAG | AAAAAATTACAAGATGTCTCCATGAAGTTTCGATTA 4380
L S Q I D V A Q | K K L Q D V S M K F R L 1460
. . . . . .
TTCCAGAAACCAGCCAATTTTGAGCAGCGTCTACAAGAAAGTAAGATGATTTTAGATGAA 4440
F Q K P A N F E Q R L Q E S K M I L D E 1480
. . . . . .
GTGAAGATGCACTTGCCTGCATTGGAAACAAAGAGTGTGGAACAGGAAGTAGTACAGTCA 4500
V K M H L P A L E T K S V E Q E V V Q S 1500
. | 33 . . . .
CAGCTAAATCATTGTGTG | AACTTGTATAAAAGTCTGAGTGAAGTGAAGTCTGAAGTGGAA 4560
Q L N H C V | N L Y K S L S E V K S E V E 1520
. . . . . .
ATGGTGATAAAGACTGGACGTCAGATTGTACAGAAAAAGCAGACGGAAAATCCCAAAGAA 4620
M V I K T G R Q I V Q K K Q T E N P K E 1540
. . . . . | 34 .
CTTGATGAAAGAGTAACAGCTTTGAAATTGCATTATAATGAGCTGGGAGCAAAG | GTAACA 4680
L D E R V T A L K L H Y N E L G A K | V T 1560
. . . . . .
GAAAGAAAGCAACAGTTGGAGAAATGCTTGAAATTGTCCCGTAAGATGCGAAAGGAAATG 4740
E R K Q Q L E K C L K L S R K M R K E M 1580
. . . . . .
AATGTCTTGACAGAATGGCTGGCAGCTACAGATATGGAATTGACAAAGAGATCAGCAGTT 4800
N V L T E W L A A T D M E L T K R S A V 1600
. . . . | 35 . .
GAAGGAATGCCTAGTAATTTGGATTCTGAAGTTGCCTGGGGAAAG | GCTACTCAAAAAGAG 4860
E G M P S N L D S E V A W G K | A T Q K E 1620
. . . . . .
ATTGAGAAACAGAAGGTGCACCTGAAGAGTATCACAGAGGTAGGAGAGGCCTTGAAAACA 4920
I E K Q K V H L K S I T E V G E A L K T 1640
. . . . . .
GTTTTGGGCAAGAAGGAGACGTTGGTGGAAGATAAACTCAGTCTTCTGAATAGTAACTGG 4980
V L G K K E T L V E D K L S L L N S N W 1660
. . . . | 36 . .
ATAGCTGTCACCTCCCGAGCAGAAGAGTGGTTAAATCTTTTGTTG | GAATACCAGAAACAC 5040
I A V T S R A E E W L N L L L | E Y Q K H 1680
. . . . . .
ATGGAAACTTTTGACCAGAATGTGGACCACATCACAAAGTGGATCATTCAGGCTGACACA 5100
M E T F D Q N V D H I T K W I I Q A D T 1700
. . . . . | 37 .
CTTTTGGATGAATCAGAGAAAAAGAAACCCCAGCAAAAAGAAGACGTGCTTAAG | CGTTTA 5160
L L D E S E K K K P Q Q K E D V L K | R L 1720
. . . . . .
AAGGCAGAACTGAATGACATACGCCCAAAGGTGGACTCTACACGTGACCAAGCAGCAAAC 5220
K A E L N D I R P K V D S T R D Q A A N 1740
. . . . . .
TTGATGGCAAACCGCGGTGACCACTGCAGGAAATTAGTAGAGCCCCAAATCTCAGAGCTC 5280
L M A N R G D H C R K L V E P Q I S E L 1760
. . . . | 38 . .
AACCATCGATTTGCAGCCATTTCACACAGAATTAAGACTGGAAAG | GCCTCCATTCCTTTG 5340
N H R F A A I S H R I K T G K | A S I P L 1780
. . . . . .
AAGGAATTGGAGCAGTTTAACTCAGATATACAAAAATTGCTTGAACCACTGGAGGCTGAA 5400
K E L E Q F N S D I Q K L L E P L E A E 1800
. . . . | 39 .
ATTCAGCAGGGGGTGAATCTGAAAGAGGAAGACTTCAATAAAGATATG | AATGAAGACAAT 5460
I Q Q G V N L K E E D F N K D M | N E D N 1820
. . . . . .
GAGGGTACTGTAAAAGAATTGTTGCAAAGAGGAGACAACTTACAACAAAGAATCACAGAT 5520
E G T V K E L L Q R G D N L Q Q R I T D 1840
. . . . . .
GAGAGAAAGCGAGAGGAAATAAAGATAAAACAGCAGCTGTTACAGACAAAACATAATGCT 5580
E R K R E E I K I K Q Q L L Q T K H N A 1860
| 40 . . . . . .
CTCAAG | GATTTGAGGTCTCAAAGAAGAAAAAAGGCTCTAGAAATTTCTCATCAGTGGTAT 5640
L K | D L R S Q R R K K A L E I S H Q W Y 1880
. . . . . .
CAGTACAAGAGGCAGGCTGATGATCTCCTGAAATGCTTGGATGACATTGAAAAAAAATTA 5700
Q Y K R Q A D D L L K C L D D I E K K L 1900
. . . | 41 . .
GCCAGCCTACCTGAGCCCAGAGATGAAAGGAAAATAAAG | GAAATTGATCGGGAATTGCAG 5760
A S L P E P R D E R K I K | E I D R E L Q 1920
. . . . . .
AAGAAGAAAGAGGAGCTGAATGCAGTGCGTAGGCAAGCTGAGGGCTTGTCTGAGGATGGG 5820
K K K E E L N A V R R Q A E G L S E D G 1940
. . . . . .
GCCGCAATGGCAGTGGAGCCAACTCAGATCCAGCTCAGCAAGCGCTGGCGGGAAATTGAG 5880
A A M A V E P T Q I Q L S K R W R E I E 1960
. . . . | 42 . .
AGCAAATTTGCTCAGTTTCGAAGACTCAACTTTGCACAAATT | CACACTGTCCGTGAAGAA 5940
S K F A Q F R R L N F A Q I | H T V R E E 1980
. . . . . .
ACGATGATGGTGATGACTGAAGACATGCCTTTGGAAATTTCTTATGTGCCTTCTACTTAT 6000
T M M V M T E D M P L E I S Y V P S T Y 2000
. . . . . .
TTGACTGAAATCACTCATGTCTCACAAGCCCTATTAGAAGTGGAACAACTTCTCAATGCT 6060
L T E I T H V S Q A L L E V E Q L L N A 2020
. . . . . | 43.
CCTGACCTCTGTGCTAAGGACTTTGAAGATCTCTTTAAGCAAGAGGAGTCTCTGAAG | AAT 6120
P D L C A K D F E D L F K Q E E S L K | N 2040
. . . . . .
ATAAAAGATAGTCTACAACAAAGCTCAGGTCGGATTGACATTATTCATAGCAAGAAGACA 6180
I K D S L Q Q S S G R I D I I H S K K T 2060
. . . . . .
GCAGCATTGCAAAGTGCAACGCCTGTGGAAAGGGTGAAGCTACAGGAAGCTCTCTCCCAG 6240
A A L Q S A T P V E R V K L Q E A L S Q 2080
. . . . . | 44 .
CTTGATTTCCAATGGGAAAAAGTTAACAAAATGTACAAGGACCGACAAGG | GCGATTTGAC 6300
L D F Q W E K V N K M Y K D R Q G | R F D 2100
. . . . . .
AGATCTGTTGAGAAATGGCGGCGTTTTCATTATGATATAAAGATATTTAATCAGTGGCTA 6360
R S V E K W R R F H Y D I K I F N Q W L 2120
. . . . . .
ACAGAAGCTGAACAGTTTCTCAGAAAGACACAAATTCCTGAGAATTGGGAACATGCTAAA 6420
T E A E Q F L R K T Q I P E N W E H A K 2140
. | 45 . . . .
TACAAATGGTATCTTAAG | GAACTCCAGGATGGCATTGGGCAGCGGCAAACTGTTGTCAGA 6480
Y K W Y L K | E L Q D G I G Q R Q T V V R 2160
. . . . . .
ACATTGAATGCAACTGGGGAAGAAATAATTCAGCAATCCTCAAAAACAGATGCCAGTATT 6540
T L N A T G E E I I Q Q S S K T D A S I 2180
. . . . . .
CTACAGGAAAAATTGGGAAGCCTGAATCTGCGGTGGCAGGAGGTCTGCAAACAGCTGTCA 6600
L Q E K L G S L N L R W Q E V C K Q L S 2200
. | 46 . . . . .
GACAGAAAAAAGAG | GCTAGAAGAACAAAAGAATATCTTGTCAGAATTTCAAAGAGATTTA 6660
D R K K R | L E E Q K N I L S E F Q R D L 2220
. . . . . .
AATGAATTTGTTTTATGGTTGGAGGAAGCAGATAACATTGCTAGTATCCCACTTGAACCT 6720
N E F V L W L E E A D N I A S I P L E P 2240
. . . . | 47 . .
GGAAAAGAGCAGCAACTAAAAGAAAAGCTTGAGCAAGTCAAG | TTACTGGTGGAAGAGTTG 6780
G K E Q Q L K E K L E Q V K | L L V E E L 2260
. . . . . .
CCCCTGCGCCAGGGAATTCTCAAACAATTAAATGAAACTGGAGGACCCGTGCTTGTAAGT 6840
P L R Q G I L K Q L N E T G G P V L V S 2280
. . . . . .
GCTCCCATAAGCCCAGAAGAGCAAGATAAACTTGAAAATAAGCTCAAGCAGACAAATCTC 6900
A P I S P E E Q D K L E N K L K Q T N L 2300
. | 48 . . . . .
CAGTGGATAAAG | GTTTCCAGAGCTTTACCTGAGAAACAAGGAGAAATTGAAGCTCAAATA 6960
Q W I K | V S R A L P E K Q G E I E A Q I 2320
. . . . . .
AAAGACCTTGGGCAGCTTGAAAAAAAGCTTGAAGACCTTGAAGAGCAGTTAAATCATCTG 7020
K D L G Q L E K K L E D L E E Q L N H L 2340
. . . . . .
CTGCTGTGGTTATCTCCTATTAGGAATCAGTTGGAAATTTATAACCAACCAAACCAAGAA 7080
L L W L S P I R N Q L E I Y N Q P N Q E 2360
. | 49 . . . .
GGACCATTTGACGTTCAG | GAAACTGAAATAGCAGTTCAAGCTAAACAACCGGATGTGGAA 7140
G P F D V Q | E T E I A V Q A K Q P D V E 2380
. . . . . .
GAGATTTTGTCTAAAGGGCAGCATTTGTACAAGGAAAAACCAGCCACTCAGCCAGTGAAG 7200
E I L S K G Q H L Y K E K P A T Q P V K 2400
| 50 . . . . . .
| AGGAAGTTAGAAGATCTGAGCTCTGAGTGGAAGGCGGTAAACCGTTTACTTCAAGAGCTG 7260
| R K L E D L S S E W K A V N R L L Q E L 2420
. . . . | 51 .
AGGGCAAAGCAGCCTGACCTAGCTCCTGGACTGACCACTATTGGAGCCT | CTCCTACTCAG 7320
R A K Q P D L A P G L T T I G A S | P T Q 2440
. . . . . .
ACTGTTACTCTGGTGACACAACCTGTGGTTACTAAGGAAACTGCCATCTCCAAACTAGAA 7380
T V T L V T Q P V V T K E T A I S K L E 2460
. . . . . .
ATGCCATCTTCCTTGATGTTGGAGGTACCTGCTCTGGCAGATTTCAACCGGGCTTGGACA 7440
M P S S L M L E V P A L A D F N R A W T 2480
. . . . . .
GAACTTACCGACTGGCTTTCTCTGCTTGATCAAGTTATAAAATCACAGAGGGTGATGGTG 7500
E L T D W L S L L D Q V I K S Q R V M V 2500
. . . . | 52 . .
GGTGACCTTGAGGATATCAACGAGATGATCATCAAGCAGAAG | GCAACAATGCAGGATTTG 7560
G D L E D I N E M I I K Q K | A T M Q D L 2520
. . . . . .
GAACAGAGGCGTCCCCAGTTGGAAGAACTCATTACCGCTGCCCAAAATTTGAAAAACAAG 7620
E Q R R P Q L E E L I T A A Q N L K N K 2540
. . . . | 53 . .
ACCAGCAATCAAGAGGCTAGAACAATCATTACGGATCGAA | TTGAAAGAATTCAGAATCAG 7680
T S N Q E A R T I I T D R I | E R I Q N Q 2560
. . . . . .
TGGGATGAAGTACAAGAACACCTTCAGAACCGGAGGCAACAGTTGAATGAAATGTTAAAG 7740
W D E V Q E H L Q N R R Q Q L N E M L K 2580
. . . . . .
GATTCAACACAATGGCTGGAAGCTAAGGAAGAAGCTGAGCAGGTCTTAGGACAGGCCAGA 7800
D S T Q W L E A K E E A E Q V L G Q A R 2600
. . . . . .
GCCAAGCTTGAGTCATGGAAGGAGGGTCCCTATACAGTAGATGCAATCCAAAAGAAAATC 7860
A K L E S W K E G P Y T V D A I Q K K I 2620
. | 54 . . . . .
ACAGAAACCAAG | CAGTTGGCCAAAGACCTCCGCCAGTGGCAGACAAATGTAGATGTGGCA 7920
T E T K | Q L A K D L R Q W Q T N V D V A 2640
. . . . . .
AATGACTTGGCCCTGAAACTTCTCCGGGATTATTCTGCAGATGATACCAGAAAAGTCCAC 7980
N D L A L K L L R D Y S A D D T R K V H 2660
. . . . | 55. .
ATGATAACAGAGAATATCAATGCCTCTTGGAGAAGCATTCATAAAAG | GGTGAGTGAGCGA 8040
M I T E N I N A S W R S I H K R | V S E R 2680
. . . . . .
GAGGCTGCTTTGGAAGAAACTCATAGATTACTGCAACAGTTCCCCCTGGACCTGGAAAAG 8100
E A A L E E T H R L L Q Q F P L D L E K 2700
. . . . . .
TTTCTTGCCTGGCTTACAGAAGCTGAAACAACTGCCAATGTCCTACAGGATGCTACCCGT 8160
F L A W L T E A E T T A N V L Q D A T R 2720
. . . . . | 56.
AAGGAAAGGCTCCTAGAAGACTCCAAGGGAGTAAAAGAGCTGATGAAACAATGGCAA | GAC 8220
K E R L L E D S K G V K E L M K Q W Q | D 2740
. . . . . .
CTCCAAGGTGAAATTGAAGCTCACACAGATGTTTATCACAACCTGGATGAAAACAGCCAA 8280
L Q G E I E A H T D V Y H N L D E N S Q 2760
. . . . . .
AAAATCCTGAGATCCCTGGAAGGTTCCGATGATGCAGTCCTGTTACAAAGACGTTTGGAT 8340
K I L R S L E G S D D A V L L Q R R L D 2780
. . . . . | 57 .
AACATGAACTTCAAGTGGAGTGAACTTCGGAAAAAGTCTCTCAACATTAG | GTCCCATTTG 8400
N M N F K W S E L R K K S L N I R | S H L 2800
. . . . . .
GAAGCCAGTTCTGACCAGTGGAAGCGTCTGCACCTTTCTCTGCAGGAACTTCTGGTGTGG 8460
E A S S D Q W K R L H L S L Q E L L V W 2820
. . . . . .
CTACAGCTGAAAGATGATGAATTAAGCCGGCAGGCACCTATTGGAGGCGACTTTCCAGCA 8520
L Q L K D D E L S R Q A P I G G D F P A 2840
. . | 58. . . .
GTTCAGAAGCAGAACGATGTACATAGG | GCCTTCAAGAGGGAATTGAAAACTAAAGAACCT 8580
V Q K Q N D V H R | A F K R E L K T K E P 2860
. . . . . .
GTAATCATGAGTACTCTTGAGACTGTACGAATATTTCTGACAGAGCAGCCTTTGGAAGGA 8640
V I M S T L E T V R I F L T E Q P L E G 2880
. . | 59 . . .
CTAGAGAAACTCTACCAGGAGCCCAGAG | AGCTGCCTCCTGAGGAGAGAGCCCAGAATGTC 8700
L E K L Y Q E P R E | L P P E E R A Q N V 2900
. . . . . .
ACTCGGCTTCTACGAAAGCAGGCTGAGGAGGTCAATACTGAGTGGGAAAAATTGAACCTG 8760
T R L L R K Q A E E V N T E W E K L N L 2920
. . . . . .
CACTCCGCTGACTGGCAGAGAAAAATAGATGAGACCCTTGAAAGACTCCAGGAACTTCAA 8820
H S A D W Q R K I D E T L E R L Q E L Q 2940
. . . . . .
GAGGCCACGGATGAGCTGGACCTCAAGCTGCGCCAAGCTGAGGTGATCAAGGGATCCTGG 8880
E A T D E L D L K L R Q A E V I K G S W 2960
. . . . . | 60.
CAGCCCGTGGGCGATCTCCTCATTGACTCTCTCCAAGATCACCTCGAGAAAGTCAAG | GCA 8940
Q P V G D L L I D S L Q D H L E K V K | A 2980
. . . . . .
CTTCGAGGAGAAATTGCGCCTCTGAAAGAGAACGTGAGCCACGTCAATGACCTTGCTCGC 9000
L R G E I A P L K E N V S H V N D L A R 3000
. . . . . .
CAGCTTACCACTTTGGGCATTCAGCTCTCACCGTATAACCTCAGCACTCTGGAAGACCTG 9060
Q L T T L G I Q L S P Y N L S T L E D L 3020
. . | 61 . . . .
AACACCAGATGGAAGCTTCTGCAG | GTGGCCGTCGAGGACCGAGTCAGGCAGCTGCATGAA 9120
N T R W K L L Q | V A V E D R V R Q L H E 3040
. . . . | 62 . .
GCCCACAGGGACTTTGGTCCAGCATCTCAGCACTTTCTTTCCA | CGTCTGTCCAGGGTCCC 9180
A H R D F G P A S Q H F L S T | S V Q G P 3060
. . . . | 63 . .
TGGGAGAGAGCCATCTCGCCAAACAAAGTGCCCTACTATATCAA | CCACGAGACTCAAACA 9240
W E R A I S P N K V P Y Y I N | H E T Q T 3080
. . . . | 64 . .
ACTTGCTGGGACCATCCCAAAATGACAGAGCTCTACCAGTCTTTAG | CTGACCTGAATAAT 9300
T C W D H P K M T E L Y Q S L A | D L N N 3100
. . . . . .
GTCAGATTCTCAGCTTATAGGACTGCCATGAAACTCCGAAGACTGCAGAAGGCCCTTTGC 9360
V R F S A Y R T A M K L R R L Q K A L C 3120
| 65 . . . . . .
T | TGGATCTCTTGAGCCTGTCAGCTGCATGTGATGCCTTGGACCAGCACAACCTCAAGCAA 9420
L | D L L S L S A A C D A L D Q H N L K Q 3140
. . . . . .
AATGACCAGCCCATGGATATCCTGCAGATTATTAATTGTTTGACCACTATTTATGACCGC 9480
N D Q P M D I L Q I I N C L T T I Y D R 3160
. . . . . .
CTGGAGCAAGAGCACAACAATTTGGTCAACGTCCCTCTCTGCGTGGATATGTGTCTGAAC 9540
L E Q E H N N L V N V P L C V D M C L N 3180
. . | 66 . . . .
TGGCTGCTGAATGTTTATGATAC | GGGACGAACAGGGAGGATCCGTGTCCTGTCTTTTAAA 9600
W L L N V Y D T | G R T G R I R V L S F K 3200
. . . . | 67 .
ACTGGCATCATTTCCCTGTGTAAAGCACATTTGGAAGACAAGTACAGAT | ACCTTTTCAAG 9660
T G I I S L C K A H L E D K Y R Y | L F K 3220
. . . . . .
CAAGTGGCAAGTTCAACAGGATTTTGTGACCAGCGCAGGCTGGGCCTCCTTCTGCATGAT 9720
Q V A S S T G F C D Q R R L G L L L H D 3240
. . . . . .
TCTATCCAAATTCCAAGACAGTTGGGTGAAGTTGCATCCTTTGGGGGCAGTAACATTGAG 9780
S I Q I P R Q L G E V A S F G G S N I E 3260
. . | 68. . . .
CCAAGTGTCCGGAGCTGCTTCCAATTT | GCTAATAATAAGCCAGAGATCGAAGCGGCCCTC 9840
P S V R S C F Q F | A N N K P E I E A A L 3280
. . . . . .
TTCCTAGACTGGATGAGACTGGAACCCCAGTCCATGGTGTGGCTGCCCGTCCTGCACAGA 9900
F L D W M R L E P Q S M V W L P V L H R 3300
. . . . . .
GTGGCTGCTGCAGAAACTGCCAAGCATCAGGCCAAATGTAACATCTGCAAAGAGTGTCCA 9960
V A A A E T A K H Q A K C N I C K E C P 3320
. | 69 . . . . .
ATCATTGGATTCAG | GTACAGGAGTCTAAAGCACTTTAATTATGACATCTGCCAAAGCTGC 10020
I I G F R | Y R S L K H F N Y D I C Q S C 3340
. . . . . .
TTTTTTTCTGGTCGAGTTGCAAAAGGCCATAAAATGCACTATCCCATGGTGGAATATTGC 10080
F F S G R V A K G H K M H Y P M V E Y C 3360
| 70 . . . . . .
ACTCCG | ACTACATCAGGAGAAGATGTTCGAGACTTTGCCAAGGTACTAAAAAACAAATTT 10140
T P | T T S G E D V R D F A K V L K N K F 3380
. . . . . .
CGAACCAAAAGGTATTTTGCGAAGCATCCCCGAATGGGCTACCTGCCAGTGCAGACTGTC 10200
R T K R Y F A K H P R M G Y L P V Q T V 3400
. . | 71 . . . .
TTAGAGGGGGACAACATGGAAAC | TCCCGTTACTCTGATCAACTTCTGGCCAGTAGATTCT 10260
L E G D N M E T | P V T L I N F W P V D S 3420
| 72 . . . . . .
GC | GCCTGCCTCGTCCCCTCAGCTTTCACACGATGATACTCATTCACGCATTGAACATTAT 10320
A | P A S S P Q L S H D D T H S R I E H Y 3440
| 73 . . . . .
GCTAGCAG | GCTAGCAGAAATGGAAAACAGCAATGGATCTTATCTAAATGATAGCATCTCT 10380
A S R | L A E M E N S N G S Y L N D S I S 3460
. | 74 . . . . .
CCTAATGAGAGCAT | AGATGATGAACATTTGTTAATCCAGCATTACTGCCAAAGTTTGAAC 10440
P N E S I | D D E H L L I Q H Y C Q S L N 3480
. . . . . .
CAGGACTCCCCCCTGAGCCAGCCTCGTAGTCCTGCCCAGATCTTGATTTCCTTAGAGAGT 10500
Q D S P L S Q P R S P A Q I L I S L E S 3500
. . . . . | 75 .
GAGGAAAGAGGGGAGCTAGAGAGAATCCTAGCAGATCTTGAGGAAGAAAACAG | GAATCTG 10560
E E R G E L E R I L A D L E E E N R | N L 3520
. . . . . .
CAAGCAGAATATGACCGTCTAAAGCAGCAGCACGAACATAAAGGCCTGTCCCCACTGCCG 10620
Q A E Y D R L K Q Q H E H K G L S P L P 3540
. . . . . .
TCCCCTCCTGAAATGATGCCCACCTCTCCCCAGAGTCCCCGGGATGCTGAGCTCATTGCT 10680
S P P E M M P T S P Q S P R D A E L I A 3560
. . . . . .
GAGGCCAAGCTACTGCGTCAACACAAAGGCCGCCTGGAAGCCAGGATGCAAATCCTGGAA 10740
E A K L L R Q H K G R L E A R M Q I L E 3580
. . . . . | 76.
GACCACAATAAACAGCTGGAGTCACAGTTACACAGGCTAAGGCAGCTGCTGGAGCAA | CCC 10800
D H N K Q L E S Q L H R L R Q L L E Q | P 3600
. . . . . .
CAGGCAGAGGCCAAAGTGAATGGCACAACGGTGTCCTCTCCTTCTACCTCTCTACAGAGG 10860
Q A E A K V N G T T V S S P S T S L Q R 3620
. . . . . .
TCCGACAGCAGTCAGCCTATGCTGCTCCGAGTGGTTGGCAGTCAAACTTCGGACTCCATG 10920
S D S S Q P M L L R V V G S Q T S D S M 3640
| 77 . . . . . .
G | GTGAGGAAGATCTTCTCAGTCCTCCCCAGGACACAAGCACAGGGTTAGAGGAGGTGATG 10980
G | E E D L L S P P Q D T S T G L E E V M 3660
. . . | 78 . . .
GAGCAACTCAACAACTCCTTCCCTAGTTCAAGAG | GAAGAAATACCCCTGGAAAGCCAATG 11040
E Q L N N S F P S S R G | R N T P G K P M 3680
| 79 .
AGAGAG | GACACAATGTAG 11058
R E | D T M * 3685
H N V G
. . . . . .
gaagtcttttccacatggcagatgatttgggcagagcgatggagtccttagtatcagtca *60
S L F H M A D D L G R A M E S L V S V M
. . . . . .
tgacagatgaagaaggagcagaataaatgttttacaactcctgattcccgcatggttttt *120
T D E E G A E *
(C-terminal end ancient dystrophin, -ex78 transcript)
. . . . . .
ataatattcatacaacaaagaggattagacagtaagagtttacaagaaataaatctatat *180
. . . . . .
ttttgtgaagggtagtggtattatactgtagatttcagtagtttctaagtctgttattgt *240
. . . . . .
tttgttaacaatggcaggttttacacgtctatgcaattgtacaaaaaagttataagaaaa *300
. . . . . .
ctacatgtaaaatcttgatagctaaataacttgccatttctttatatggaacgcattttg *360
. . . . . .
ggttgtttaaaaatttataacagttataaagaaagattgtaaactaaagtgtgctttata *420
. . . . . .
aaaaaaagttgtttataaaaacccctaaaaacaaaacaaacacacacacacacacataca *480
. . . . . .
cacacacacacaaaactttgaggcagcgcattgttttgcatccttttggcgtgatatcca *540
. . . . . .
tatgaaattcatggctttttctttttttgcatattaaagataagacttcctctaccacca *600
. . . . . .
caccaaatgactactacacactgctcatttgagaactgtcagctgagtggggcaggcttg *660
. . . . . .
agttttcatttcatatatctatatgtctataagtatataaatactatagttatatagata *720
. . . . . .
aagagatacgaatttctatagactgactttttccattttttaaatgttcatgtcacatcc *780
. . . . . .
taatagaaagaaattacttctagtcagtcatccaggcttacctgcttggtctagaatgga *840
. . . . . .
tttttcccggagccggaagccaggaggaaactacaccacactaaaacattgtctacagct *900
. . . . . .
ccagatgtttctcattttaaacaactttccactgacaacgaaagtaaagtaaagtattgg *960
. . . . . .
atttttttaaagggaacatgtgaatgaatacacaggacttattatatcagagtgagtaat *1020
. . . . . .
cggttggttggttgattgattgattgattgatacattcagcttcctgctgctagcaatgc *1080
. . . . . .
cacgatttagatttaatgatgcttcagtggaaatcaatcagaaggtattctgaccttgtg *1140
. . . . . .
aacatcagaaggtattttttaactcccaagcagtagcaggacgatgatagggctggaggg *1200
. . . . . .
ctatggattcccagcccatccctgtgaaggagtaggccactctttaagtgaaggattgga *1260
. . . . . .
tgattgttcataatacataaagttctctgtaattacaactaaattattatgccctcttct *1320
. . . . . .
cacagtcaaaaggaactgggtggtttggtttttgttgcttttttagatttattgtcccat *1380
. . . . . .
gtgggatgagtttttaaatgccacaagacataatttaaaataaataaactttgggaaaag *1440
. . . . . .
gtgtaaaacagtagccccatcacatttgtgatactgacaggtatcaacccagaagcccat *1500
. . . . . .
gaactgtgtttccatcctttgcatttctctgcgagtagttccacacaggtttgtaagtaa *1560
. . . . . .
gtaagaaagaaggcaaattgattcaaatgttacaaaaaaacccttcttggtggattagac *1620
. . . . . .
aggttaaatatataaacaaacaaacaaaaattgctcaaaaaagaggagaaaagctcaaga *1680
. . . . . .
ggaaaagctaaggactggtaggaaaaagctttactctttcatgccattttatttcttttt *1740
. . . . . .
gatttttaaatcattcattcaatagataccaccgtgtgacctataattttgcaaatctgt *1800
. . . . . .
tacctctgacatcaagtgtaattagcttttggagagtgggctgacatcaagtgtaattag *1860
. . . . . .
cttttggagagtgggttttgtccattattaataattaattaattaacatcaaacacggct *1920
. . . . . .
tctcatgctatttctacctcactttggttttggggtgttcctgataattgtgcacacctg *1980
. . . . . .
agttcacagcttcaccacttgtccattgcgttattttctttttcctttataattctttct *2040
. . . . . .
ttttccttcataattttcaaaagaaaacccaaagctctaaggtaacaaattaccaaatta *2100
. . . . . .
catgaagatttggtttttgtcttgcatttttttcctttatgtgacgctggaccttttctt *2160
. . . . . .
tacccaaggatttttaaaactcagatttaaaacaaggggttactttacatcctactaaga *2220
. . . . . .
agtttaagtaagtaagtttcattctaaaatcagaggtaaatagagtgcataaataatttt *2280
. . . . . .
gttttaatctttttgtttttcttttagacacattagctctggagtgagtctgtcataata *2340
. . . . . .
tttgaacaaaaattgagagctttattgctgcattttaagcataattaatttggacattat *2400
. . . . . .
ttcgtgttgtgttctttataaccaccaagtattaaactgtaaatcataatgtaactgaag *2460
. . . . . .
cataaacatcacatggcatgttttgtcattgttttcaggtactgagttcttacttgagta *2520
. . . . . .
tcataatatattgtgttttaacaccaacactgtaacatttacgaattatttttttaaact *2580
. . . . . .
tcagttttactgcattttcacaacatatcagacttcaccaaatatatgccttactattgt *2640
. . . . .
attatagtactgctttactgtgtatctcaataaagcacgcagttatgttac *2691
(downstream sequence)
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