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DMD-gene exon 14 / 15

(used for mutation description)

(last modified July 10, 2001)

consensus sequence derived from AC004468

intron 13

   .         .         .         .         .
   aaaatctacatagtaatagaatttaagttactaagaattttcttctacaa    -451
   .         .         .         .         .
   tccaaatggtaggcaattctcattatgcaagattgtttcaattaagagtc    -401
   .         .         .         .         .
   ttttgaggcattctatttagtagttagacttttattctttagggtgtatt    -351
   .         .         .         .         .
   ttcaaacctaaggaaaatacaccttttacttgttctcactgcaaaatcct    -301
   .         .         .         .         .
   ctctatatgtatgtctttgttatcttacatttgctatggagccattttat    -251
   .         .         .         .         .
   atagtggtataataaccacttcatattgcttgtctctttgcttttctatg    -201
   .         .         .         .         .
   aaaggtacaagacttggtgagataaagacaaatgacagtcacaccactta    -151
   .         .         .         .         .
   tttaaatgtaagcagatcagaaagagtgtcccttccaacttctagcgtac    -101
   .         .         .         .         .
   ataggagactgagatactttggcaaattattcatgccatttttaataaaa    -51
   .         .         .         .         .
   cgtagttaccaattgtttgctgatgctgtgcttgattgtctcttctccag    -1

exon 14

1811        .         .         .         .         .
   GTATTGGGAGATCGATGGGCAAACATCTGTAGATGGACAGAAGACCGCTG   1860
   V  L  G  D  R  W  A  N  I  C  R  W  T  E  D  R  W     551
 535
            .         .         .         .         .
   GGTTCTTTTACAAGACATCCTTCTCAAATGGCAACGTCTTACTGAAGAAC   1910
    V  L  L  Q  D  I  L  L  K  W  Q  R  L  T  E  E  Q    568


1912  |
   AG |                                                 1913

intron 14

  +1        .         .         .         .         .
   gtgtgtcatgtgtgagaaactagctgtaaaagacacggggggatattaaattg    +53

 -54   .         .         .         .         .         
   gaaaagtaaagatttatgtttatttattccttggaattctttaatgtcttgcag   -1

exon 15

1913      .         .         .         .         .
   TGCCTTTTTAGTGCATGGCTTTCAGAAAAAGAAGATGCAGTGAACAAGAT   1960
   C  L  F  S  A  W  L  S  E  K  E  D  A  V  N  K  I     585
 569
            .         .         .         .         .
   TCACACAACTGGCTTTAAAGATCAAAATGAAATGTTATCAAGTCTTCAAA   2010
    H  T  T  G  F  K  D  Q  N  E  M  L  S  S  L  Q  K    602

       2020
   AACTGGCC |                                           2020
     L  A                                                604

intron 15

  +1        .         .         .         .         .
   gtatgtactttctagctttcaatggtcttataaaaacccagtactgtata    +50
            .         .         .         .         .
   ttatcactattatttagtctcttctatgctattgaatattaaatgtttat    +100
            .         .         .         .         .
   ttttgcttggatcatagattattcaaagatgttatattgctacttttctg    +150
            .         .         .         .         .
   aattaaagtgggaaaaaactataggtggattttcaactttgtttttcaaa    +200
            .         .         .         .         .
   gttgtactcttgataaaacatagcataccagaataagacttcaattaaaa    +250
            .         .         .         .         .
   ttaataaagtaatactaagaaatgtctgtgagcctttcataaagttctaa    +300
            .         .         .         .         .
   gcagcatagttctaaaaaaatagactgacgttgattctcagaataatatg    +350
            .         .         .         .         .
   tgagagttacaagcgacggttatcctgacattgatggagtttaaccttag    +400
            .         .         .         .         .
   tttattataaaggggtacctgagactgggactgggtaacttatgaaataa    +450
            .         .         .         .         .
   agaggtttaactggctcatggttctgcaggctgtacaagaagcatgacac    +500

Legend:
DMD-gene exon Reference Sequence for the description of sequence variations (DMD-gene sequence variation database). Shown are 500 bp directly upstream from the splice acceptor site (numbered from -500 to -1), the exon sequence (numbered as in the cDNA Reference Sequence) and 500 bp directly downstream from the splice donor site. Intronic sequences are in lower case, exonic sequences in UPPER CASE lettering. Encoded amino acids are shown in the one-letter amino acid code. Known polymorphic sites (frequence > 0.01) are shown in bold-italics. Primers used for DHPLC are indicated in red.