(last modified March 2, 1999)
Submitted to GenBank
LOCUS Dp427l 13764 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp427l (lymphocyte).
ACCESSION Dp427l
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 46)
AUTHORS Nishio,H., Takeshima,Y., Narita,N., Yanagawa,H., Suzuki,Y.,
Ishikawa,Y., Ishikawa,Y., Minami,R., Nakamura,H. and Matsuo,M.
TITLE Identification of a novel first exon in the human dystrophin gene
and of a new promoter located more than 500 kb upstream of the
nearest known promoter
JOURNAL J. Clin. Invest. 94, 1037-1042 (1994)
REFERENCE 2 (sites)
AUTHORS Muntoni,F., Melis,M.A., Ganau,A. and Dubowitz,V.
TITLE Transcription of the dystrophin gene in normal tissues and in
skeletal muscle of a family with X-linked dilated cardiomyopathy
JOURNAL Am.J.Hum.Genet. 56, 151-157 (1995)
REFERENCE 3 (bases 1 to 13764)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
COMMENT Constructed consensus sequence of D32048 and M18533.
FEATURES Location/Qualifiers
source 1..13764
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
5'UTR <1..384
misc_feature 47..108
/note="Nishio et al. state that bases 47-108 (dystrophin
exon 2) are not in the transcript, while Muntoni et al.
state they are"
/citation=[2]
/citation=[1]
CDS 385..11073
/note="location of the translation initiation start is
unclear."
/codon_start=1
/product="dystrophin Dp427l"
/translation="MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGL
ALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDK
KSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLA
QGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNL
DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNI
LQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKL
KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV
VVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA
WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL
KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT
TREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF
AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS
EQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP
TAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV
FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRL
GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV
EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV
SDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK
GGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE
AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWH
ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILA
QTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQES
LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ
IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ
LNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV
TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKAT
QKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLL
EYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS
TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQ
KLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKI
KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR
DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ
FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL
CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL
DFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA
KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKL
LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ
GEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA
VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAP
GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS
LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE
ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKL
ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM
ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQR
RLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIG
GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP
EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR
QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL
SPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP
NKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLS
LSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDS
IQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLH
RVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMV
EYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINF
WPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQ
HYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH
EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
LHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS
PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature <385..735
/note="Region: Actin binding domain"
misc_feature 772..9135
/note="Region: central rod domain"
772..9135
misc_feature 772..996
/note="Region: hinge region 1"
misc_feature 1024..1356
/note="Region: repeat region 1"
misc_feature 1357..1683
/note="Region: repeat region 2"
misc_feature 1684..2016
/note="Region: repeat region 3"
misc_feature 2017..2166
/note="Region: hinge region 2"
misc_feature 2167..2499
/note="Region: repeat region 4"
misc_feature 2500..2817
/note="Region: repeat region 5"
misc_feature 2818..3150
/note="Region: repeat region 6"
misc_feature 3151..3477
/note="Region: repeat region 7"
misc_feature 3478..3804
/note="Region: repeat region 8"
misc_feature 3805..4116
/note="Region: repeat region 9"
misc_feature 4021..4086
/note="Region: dystrophin Dp260-1 unique N-terminus"
misc_feature 4117..4404
/note="Region: repeat region 10"
misc_feature 4396..4719
/note="Region: repeat region 11"
misc_feature 4720..5043
/note="Region: repeat region 12"
misc_feature 5044..5349
/note="Region: repeat region 13"
misc_feature 5350..5637
/note="Region: repeat region 14"
misc_feature 5638..5934
/note="Region: repeat region 15"
misc_feature 5989..6318
/note="Region: repeat region 16"
misc_feature 6319..6639
/note="Region: repeat region 17"
misc_feature 6640..6969
/note="Region: repeat region 18"
misc_feature 6970..7284
/note="Region: repeat region 19"
misc_feature 7285..7425
/note="Region: hinge region 3"
misc_feature 7426..7746
/note="Region: repeat region 20"
misc_feature 7747..8073
/note="Region: repeat region 21"
misc_feature 8074..8421
/note="Region: repeat region 22"
misc_feature 8422..8808
/note="Region: repeat region 23"
misc_feature 8809..9135
/note="Region: repeat region 24"
misc_feature 9055..9351
/note="Region: hinge region 4"
misc_feature 9181..9291
/note="Region: WW-domain"
misc_feature 9253..10239
/note="dystroglycan binding site"
misc_feature 9313..9915
/note="Region: Cysteine-rich domain"
misc_feature 9403..9486
/note="Region: EF-hand 1"
misc_feature 9547..9633
/note="Region: EF-hand 2"
misc_feature 9913..11070
/note="Region: Carboxy-terminal region"
misc_feature 9934..10077
/note="Region: ZZ-domain"
misc_feature 10345..10497
/note="alpha1-syntrophin binding site"
misc_feature 10498..10620
/note="beta1-syntrophin binding site"
misc_feature 10498..10620
/note="Region: beta1-syntrophin binding site"
misc_feature 10687..10794
/note="Region: (Leu)6-heptad repeat"
3'UTR 11074..13764
polyA_signal 13742..13748
polyA_site 13764
BASE COUNT 4550 a 2754 c 3076 g 3384 t
ORIGIN
1 tcactgacac atagagtaac ttctagttct ccaagctcta ctcatgatga aagagaagat
61 gttcaaaaga aaacattcac aaaatgggta aatgcacaat tttctaagtt tgggaagcag
121 catattgaga acctcttcag tgacctacag gatgggaggc gcctcctaga cctcctcgaa
181 ggcctgacag ggcaaaaact gccaaaagaa aaaggatcca caagagttca tgccctgaac
241 aatgtcaaca aggcactgcg ggttttgcag aacaataatg ttgatttagt gaatattgga
301 agtactgaca tcgtagatgg aaatcataaa ctgactcttg gtttgatttg gaatataatc
361 ctccactggc aggtcaaaaa tgtaatgaaa aatatcatgg ctggattgca acaaaccaac
421 agtgaaaaga ttctcctgag ctgggtccga caatcaactc gtaattatcc acaggttaat
481 gtaatcaact tcaccaccag ctggtctgat ggcctggctt tgaatgctct catccatagt
541 cataggccag acctatttga ctggaatagt gtggtttgcc agcagtcagc cacacaacga
601 ctggaacatg cattcaacat cgccagatat caattaggca tagagaaact actcgatcct
661 gaagatgttg ataccaccta tccagataag aagtccatct taatgtacat cacatcactc
721 ttccaagttt tgcctcaaca agtgagcatt gaagccatcc aggaagtgga aatgttgcca
781 aggccaccta aagtgactaa agaagaacat tttcagttac atcatcaaat gcactattct
841 caacagatca cggtcagtct agcacaggga tatgagagaa cttcttcccc taagcctcga
901 ttcaagagct atgcctacac acaggctgct tatgtcacca cctctgaccc tacacggagc
961 ccatttcctt cacagcattt ggaagctcct gaagacaagt catttggcag ttcattgatg
1021 gagagtgaag taaacctgga ccgttatcaa acagctttag aagaagtatt atcgtggctt
1081 ctttctgctg aggacacatt gcaagcacaa ggagagattt ctaatgatgt ggaagtggtg
1141 aaagaccagt ttcatactca tgaggggtac atgatggatt tgacagccca tcagggccgg
1201 gttggtaata ttctacaatt gggaagtaag ctgattggaa caggaaaatt atcagaagat
1261 gaagaaactg aagtacaaga gcagatgaat ctcctaaatt caagatggga atgcctcagg
1321 gtagctagca tggaaaaaca aagcaattta catagagttt taatggatct ccagaatcag
1381 aaactgaaag agttgaatga ctggctaaca aaaacagaag aaagaacaag gaaaatggag
1441 gaagagcctc ttggacctga tcttgaagac ctaaaacgcc aagtacaaca acataaggtg
1501 cttcaagaag atctagaaca agaacaagtc agggtcaatt ctctcactca catggtggtg
1561 gtagttgatg aatctagtgg agatcacgca actgctgctt tggaagaaca acttaaggta
1621 ttgggagatc gatgggcaaa catctgtaga tggacagaag accgctgggt tcttttacaa
1681 gacatccttc tcaaatggca acgtcttact gaagaacagt gcctttttag tgcatggctt
1741 tcagaaaaag aagatgcagt gaacaagatt cacacaactg gctttaaaga tcaaaatgaa
1801 atgttatcaa gtcttcaaaa actggccgtt ttaaaagcgg atctagaaaa gaaaaagcaa
1861 tccatgggca aactgtattc actcaaacaa gatcttcttt caacactgaa gaataagtca
1921 gtgacccaga agacggaagc atggctggat aactttgccc ggtgttggga taatttagtc
1981 caaaaacttg aaaagagtac agcacagatt tcacaggctg tcaccaccac tcagccatca
2041 ctaacacaga caactgtaat ggaaacagta actacggtga ccacaaggga acagatcctg
2101 gtaaagcatg ctcaagagga acttccacca ccacctcccc aaaagaagag gcagattact
2161 gtggattctg aaattaggaa aaggttggat gttgatataa ctgaacttca cagctggatt
2221 actcgctcag aagctgtgtt gcagagtcct gaatttgcaa tctttcggaa ggaaggcaac
2281 ttctcagact taaaagaaaa agtcaatgcc atagagcgag aaaaagctga gaagttcaga
2341 aaactgcaag atgccagcag atcagctcag gccctggtgg aacagatggt gaatgagggt
2401 gttaatgcag atagcatcaa acaagcctca gaacaactga acagccggtg gatcgaattc
2461 tgccagttgc taagtgagag acttaactgg ctggagtatc agaacaacat catcgctttc
2521 tataatcagc tacaacaatt ggagcagatg acaactactg ctgaaaactg gttgaaaatc
2581 caacccacca ccccatcaga gccaacagca attaaaagtc agttaaaaat ttgtaaggat
2641 gaagtcaacc ggctatcagg tcttcaacct caaattgaac gattaaaaat tcaaagcata
2701 gccctgaaag agaaaggaca aggacccatg ttcctggatg cagactttgt ggcctttaca
2761 aatcatttta agcaagtctt ttctgatgtg caggccagag agaaagagct acagacaatt
2821 tttgacactt tgccaccaat gcgctatcag gagaccatga gtgccatcag gacatgggtc
2881 cagcagtcag aaaccaaact ctccatacct caacttagtg tcaccgacta tgaaatcatg
2941 gagcagagac tcggggaatt gcaggcttta caaagttctc tgcaagagca acaaagtggc
3001 ctatactatc tcagcaccac tgtgaaagag atgtcgaaga aagcgccctc tgaaattagc
3061 cggaaatatc aatcagaatt tgaagaaatt gagggacgct ggaagaagct ctcctcccag
3121 ctggttgagc attgtcaaaa gctagaggag caaatgaata aactccgaaa aattcagaat
3181 cacatacaaa ccctgaagaa atggatggct gaagttgatg tttttctgaa ggaggaatgg
3241 cctgcccttg gggattcaga aattctaaaa aagcagctga aacagtgcag acttttagtc
3301 agtgatattc agacaattca gcccagtcta aacagtgtca atgaaggtgg gcagaagata
3361 aagaatgaag cagagccaga gtttgcttcg agacttgaga cagaactcaa agaacttaac
3421 actcagtggg atcacatgtg ccaacaggtc tatgccagaa aggaggcctt gaagggaggt
3481 ttggagaaaa ctgtaagcct ccagaaagat ctatcagaga tgcacgaatg gatgacacaa
3541 gctgaagaag agtatcttga gagagatttt gaatataaaa ctccagatga attacagaaa
3601 gcagttgaag agatgaagag agctaaagaa gaggcccaac aaaaagaagc gaaagtgaaa
3661 ctccttactg agtctgtaaa tagtgtcata gctcaagctc cacctgtagc acaagaggcc
3721 ttaaaaaagg aacttgaaac tctaaccacc aactaccagt ggctctgcac taggctgaat
3781 gggaaatgca agactttgga agaagtttgg gcatgttggc atgagttatt gtcatacttg
3841 gagaaagcaa acaagtggct aaatgaagta gaatttaaac ttaaaaccac tgaaaacatt
3901 cctggcggag ctgaggaaat ctctgaggtg ctagattcac ttgaaaattt gatgcgacat
3961 tcagaggata acccaaatca gattcgcata ttggcacaga ccctaacaga tggcggagtc
4021 atggatgagc taatcaatga ggaacttgag acatttaatt ctcgttggag ggaactacat
4081 gaagaggctg taaggaggca aaagttgctt gaacagagca tccagtctgc ccaggagact
4141 gaaaaatcct tacacttaat ccaggagtcc ctcacattca ttgacaagca gttggcagct
4201 tatattgcag acaaggtgga cgcagctcaa atgcctcagg aagcccagaa aatccaatct
4261 gatttgacaa gtcatgagat cagtttagaa gaaatgaaga aacataatca ggggaaggag
4321 gctgcccaaa gagtcctgtc tcagattgat gttgcacaga aaaaattaca agatgtctcc
4381 atgaagtttc gattattcca gaaaccagcc aattttgagc agcgtctaca agaaagtaag
4441 atgattttag atgaagtgaa gatgcacttg cctgcattgg aaacaaagag tgtggaacag
4501 gaagtagtac agtcacagct aaatcattgt gtgaacttgt ataaaagtct gagtgaagtg
4561 aagtctgaag tggaaatggt gataaagact ggacgtcaga ttgtacagaa aaagcagacg
4621 gaaaatccca aagaacttga tgaaagagta acagctttga aattgcatta taatgagctg
4681 ggagcaaagg taacagaaag aaagcaacag ttggagaaat gcttgaaatt gtcccgtaag
4741 atgcgaaagg aaatgaatgt cttgacagaa tggctggcag ctacagatat ggaattgaca
4801 aagagatcag cagttgaagg aatgcctagt aatttggatt ctgaagttgc ctggggaaag
4861 gctactcaaa aagagattga gaaacagaag gtgcacctga agagtatcac agaggtagga
4921 gaggccttga aaacagtttt gggcaagaag gagacgttgg tggaagataa actcagtctt
4981 ctgaatagta actggatagc tgtcacctcc cgagcagaag agtggttaaa tcttttgttg
5041 gaataccaga aacacatgga aacttttgac cagaatgtgg accacatcac aaagtggatc
5101 attcaggctg acacactttt ggatgaatca gagaaaaaga aaccccagca aaaagaagac
5161 gtgcttaagc gtttaaaggc agaactgaat gacatacgcc caaaggtgga ctctacacgt
5221 gaccaagcag caaacttgat ggcaaaccgc ggtgaccact gcaggaaatt agtagagccc
5281 caaatctcag agctcaacca tcgatttgca gccatttcac acagaattaa gactggaaag
5341 gcctccattc ctttgaagga attggagcag tttaactcag atatacaaaa attgcttgaa
5401 ccactggagg ctgaaattca gcagggggtg aatctgaaag aggaagactt caataaagat
5461 atgaatgaag acaatgaggg tactgtaaaa gaattgttgc aaagaggaga caacttacaa
5521 caaagaatca cagatgagag aaagcgagag gaaataaaga taaaacagca gctgttacag
5581 acaaaacata atgctctcaa ggatttgagg tctcaaagaa gaaaaaaggc tctagaaatt
5641 tctcatcagt ggtatcagta caagaggcag gctgatgatc tcctgaaatg cttggatgac
5701 attgaaaaaa aattagccag cctacctgag cccagagatg aaaggaaaat aaaggaaatt
5761 gatcgggaat tgcagaagaa gaaagaggag ctgaatgcag tgcgtaggca agctgagggc
5821 ttgtctgagg atggggccgc aatggcagtg gagccaactc agatccagct cagcaagcgc
5881 tggcgggaaa ttgagagcaa atttgctcag tttcgaagac tcaactttgc acaaattcac
5941 actgtccgtg aagaaacgat gatggtgatg actgaagaca tgcctttgga aatttcttat
6001 gtgccttcta cttatttgac tgaaatcact catgtctcac aagccctatt agaagtggaa
6061 caacttctca atgctcctga cctctgtgct aaggactttg aagatctctt taagcaagag
6121 gagtctctga agaatataaa agatagtcta caacaaagct caggtcggat tgacattatt
6181 catagcaaga agacagcagc attgcaaagt gcaacgcctg tggaaagggt gaagctacag
6241 gaagctctct cccagcttga tttccaatgg gaaaaagtta acaaaatgta caaggaccga
6301 caagggcgat ttgacagatc tgttgagaaa tggcggcgtt ttcattatga tataaagata
6361 tttaatcagt ggctaacaga agctgaacag tttctcagaa agacacaaat tcctgagaat
6421 tgggaacatg ctaaatacaa atggtatctt aaggaactcc aggatggcat tgggcagcgg
6481 caaactgttg tcagaacatt gaatgcaact ggggaagaaa taattcagca atcctcaaaa
6541 acagatgcca gtattctaca ggaaaaattg ggaagcctga atctgcggtg gcaggaggtc
6601 tgcaaacagc tgtcagacag aaaaaagagg ctagaagaac aaaagaatat cttgtcagaa
6661 tttcaaagag atttaaatga atttgtttta tggttggagg aagcagataa cattgctagt
6721 atcccacttg aacctggaaa agagcagcaa ctaaaagaaa agcttgagca agtcaagtta
6781 ctggtggaag agttgcccct gcgccaggga attctcaaac aattaaatga aactggagga
6841 cccgtgcttg taagtgctcc cataagccca gaagagcaag ataaacttga aaataagctc
6901 aagcagacaa atctccagtg gataaaggtt tccagagctt tacctgagaa acaaggagaa
6961 attgaagctc aaataaaaga ccttgggcag cttgaaaaaa agcttgaaga ccttgaagag
7021 cagttaaatc atctgctgct gtggttatct cctattagga atcagttgga aatttataac
7081 caaccaaacc aagaaggacc atttgacgtt caggaaactg aaatagcagt tcaagctaaa
7141 caaccggatg tggaagagat tttgtctaaa gggcagcatt tgtacaagga aaaaccagcc
7201 actcagccag tgaagaggaa gttagaagat ctgagctctg agtggaaggc ggtaaaccgt
7261 ttacttcaag agctgagggc aaagcagcct gacctagctc ctggactgac cactattgga
7321 gcctctccta ctcagactgt tactctggtg acacaacctg tggttactaa ggaaactgcc
7381 atctccaaac tagaaatgcc atcttccttg atgttggagg tacctgctct ggcagatttc
7441 aaccgggctt ggacagaact taccgactgg ctttctctgc ttgatcaagt tataaaatca
7501 cagagggtga tggtgggtga ccttgaggat atcaacgaga tgatcatcaa gcagaaggca
7561 acaatgcagg atttggaaca gaggcgtccc cagttggaag aactcattac cgctgcccaa
7621 aatttgaaaa acaagaccag caatcaagag gctagaacaa tcattacgga tcgaattgaa
7681 agaattcaga atcagtggga tgaagtacaa gaacaccttc agaaccggag gcaacagttg
7741 aatgaaatgt taaaggattc aacacaatgg ctggaagcta aggaagaagc tgagcaggtc
7801 ttaggacagg ccagagccaa gcttgagtca tggaaggagg gtccctatac agtagatgca
7861 atccaaaaga aaatcacaga aaccaagcag ttggccaaag acctccgcca gtggcagaca
7921 aatgtagatg tggcaaatga cttggccctg aaacttctcc gggattattc tgcagatgat
7981 accagaaaag tccacatgat aacagagaat atcaatgcct cttggagaag cattcataaa
8041 agggtgagtg agcgagaggc tgctttggaa gaaactcata gattactgca acagttcccc
8101 ctggacctgg aaaagtttct tgcctggctt acagaagctg aaacaactgc caatgtccta
8161 caggatgcta cccgtaagga aaggctccta gaagactcca agggagtaaa agagctgatg
8221 aaacaatggc aagacctcca aggtgaaatt gaagctcaca cagatgttta tcacaacctg
8281 gatgaaaaca gccaaaaaat cctgagatcc ctggaaggtt ccgatgatgc agtcctgtta
8341 caaagacgtt tggataacat gaacttcaag tggagtgaac ttcggaaaaa gtctctcaac
8401 attaggtccc atttggaagc cagttctgac cagtggaagc gtctgcacct ttctctgcag
8461 gaacttctgg tgtggctaca gctgaaagat gatgaattaa gccggcaggc acctattgga
8521 ggcgactttc cagcagttca gaagcagaac gatgtacata gggccttcaa gagggaattg
8581 aaaactaaag aacctgtaat catgagtact cttgagactg tacgaatatt tctgacagag
8641 cagcctttgg aaggactaga gaaactctac caggagccca gagagctgcc tcctgaggag
8701 agagcccaga atgtcactcg gcttctacga aagcaggctg aggaggtcaa tactgagtgg
8761 gaaaaattga acctgcactc cgctgactgg cagagaaaaa tagatgagac ccttgaaaga
8821 ctccaggaac ttcaagaggc cacggatgag ctggacctca agctgcgcca agctgaggtg
8881 atcaagggat cctggcagcc cgtgggcgat ctcctcattg actctctcca agatcacctc
8941 gagaaagtca aggcacttcg aggagaaatt gcgcctctga aagagaacgt gagccacgtc
9001 aatgaccttg ctcgccagct taccactttg ggcattcagc tctcaccgta taacctcagc
9061 actctggaag acctgaacac cagatggaag cttctgcagg tggccgtcga ggaccgagtc
9121 aggcagctgc atgaagccca cagggacttt ggtccagcat ctcagcactt tctttccacg
9181 tctgtccagg gtccctggga gagagccatc tcgccaaaca aagtgcccta ctatatcaac
9241 cacgagactc aaacaacttg ctgggaccat cccaaaatga cagagctcta ccagtcttta
9301 gctgacctga ataatgtcag attctcagct tataggactg ccatgaaact ccgaagactg
9361 cagaaggccc tttgcttgga tctcttgagc ctgtcagctg catgtgatgc cttggaccag
9421 cacaacctca agcaaaatga ccagcccatg gatatcctgc agattattaa ttgtttgacc
9481 actatttatg accgcctgga gcaagagcac aacaatttgg tcaacgtccc tctctgcgtg
9541 gatatgtgtc tgaactggct gctgaatgtt tatgatacgg gacgaacagg gaggatccgt
9601 gtcctgtctt ttaaaactgg catcatttcc ctgtgtaaag cacatttgga agacaagtac
9661 agataccttt tcaagcaagt ggcaagttca acaggatttt gtgaccagcg caggctgggc
9721 ctccttctgc atgattctat ccaaattcca agacagttgg gtgaagttgc atcctttggg
9781 ggcagtaaca ttgagccaag tgtccggagc tgcttccaat ttgctaataa taagccagag
9841 atcgaagcgg ccctcttcct agactggatg agactggaac cccagtccat ggtgtggctg
9901 cccgtcctgc acagagtggc tgctgcagaa actgccaagc atcaggccaa atgtaacatc
9961 tgcaaagagt gtccaatcat tggattcagg tacaggagtc taaagcactt taattatgac
10021 atctgccaaa gctgcttttt ttctggtcga gttgcaaaag gccataaaat gcactatccc
10081 atggtggaat attgcactcc gactacatca ggagaagatg ttcgagactt tgccaaggta
10141 ctaaaaaaca aatttcgaac caaaaggtat tttgcgaagc atccccgaat gggctacctg
10201 ccagtgcaga ctgtcttaga gggggacaac atggaaactc ccgttactct gatcaacttc
10261 tggccagtag attctgcgcc tgcctcgtcc cctcagcttt cacacgatga tactcattca
10321 cgcattgaac attatgctag caggctagca gaaatggaaa acagcaatgg atcttatcta
10381 aatgatagca tctctcctaa tgagagcata gatgatgaac atttgttaat ccagcattac
10441 tgccaaagtt tgaaccagga ctcccccctg agccagcctc gtagtcctgc ccagatcttg
10501 atttccttag agagtgagga aagaggggag ctagagagaa tcctagcaga tcttgaggaa
10561 gaaaacagga atctgcaagc agaatatgac cgtctaaagc agcagcacga acataaaggc
10621 ctgtccccac tgccgtcccc tcctgaaatg atgcccacct ctccccagag tccccgggat
10681 gctgagctca ttgctgaggc caagctactg cgtcaacaca aaggccgcct ggaagccagg
10741 atgcaaatcc tggaagacca caataaacag ctggagtcac agttacacag gctaaggcag
10801 ctgctggagc aaccccaggc agaggccaaa gtgaatggca caacggtgtc ctctccttct
10861 acctctctac agaggtccga cagcagtcag cctatgctgc tccgagtggt tggcagtcaa
10921 acttcggact ccatgggtga ggaagatctt ctcagtcctc cccaggacac aagcacaggg
10981 ttagaggagg tgatggagca actcaacaac tccttcccta gttcaagagg aagaaatacc
11041 cctggaaagc caatgagaga ggacacaatg taggaagtct tttccacatg gcagatgatt
11101 tgggcagagc gatggagtcc ttagtatcag tcatgacaga tgaagaagga gcagaataaa
11161 tgttttacaa ctcctgattc ccgcatggtt tttataatat tcatacaaca aagaggatta
11221 gacagtaaga gtttacaaga aataaatcta tatttttgtg aagggtagtg gtattatact
11281 gtagatttca gtagtttcta agtctgttat tgttttgtta acaatggcag gttttacacg
11341 tctatgcaat tgtacaaaaa agttataaga aaactacatg taaaatcttg atagctaaat
11401 aacttgccat ttctttatat ggaacgcatt ttgggttgtt taaaaattta taacagttat
11461 aaagaaagat tgtaaactaa agtgtgcttt ataaaaaaaa gttgtttata aaaaccccta
11521 aaaacaaaac aaacacacac acacacacat acacacacac acacaaaact ttgaggcagc
11581 gcattgtttt gcatcctttt ggcgtgatat ccatatgaaa ttcatggctt tttctttttt
11641 tgcatattaa agataagact tcctctacca ccacaccaaa tgactactac acactgctca
11701 tttgagaact gtcagctgag tggggcaggc ttgagttttc atttcatata tctatatgtc
11761 tataagtata taaatactat agttatatag ataaagagat acgaatttct atagactgac
11821 tttttccatt ttttaaatgt tcatgtcaca tcctaataga aagaaattac ttctagtcag
11881 tcatccaggc ttacctgctt ggtctagaat ggatttttcc cggagccgga agccaggagg
11941 aaactacacc acactaaaac attgtctaca gctccagatg tttctcattt taaacaactt
12001 tccactgaca acgaaagtaa agtaaagtat tggatttttt taaagggaac atgtgaatga
12061 atacacagga cttattatat cagagtgagt aatcggttgg ttggttgatt gattgattga
12121 ttgatacatt cagcttcctg ctgctagcaa tgccacgatt tagatttaat gatgcttcag
12181 tggaaatcaa tcagaaggta ttctgacctt gtgaacatca gaaggtattt tttaactccc
12241 aagcagtagc aggacgatga tagggctgga gggctatgga ttcccagccc atccctgtga
12301 aggagtaggc cactctttaa gtgaaggatt ggatgattgt tcataataca taaagttctc
12361 tgtaattaca actaaattat tatgccctct tctcacagtc aaaaggaact gggtggtttg
12421 gtttttgttg cttttttaga tttattgtcc catgtgggat gagtttttaa atgccacaag
12481 acataattta aaataaataa actttgggaa aaggtgtaag acagtagccc catcacattt
12541 gtgatactga caggtatcaa cccagaagcc catgaactgt gtttccatcc tttgcatttc
12601 tctgcgagta gttccacaca ggtttgtaag taagtaagaa agaaggcaaa ttgattcaaa
12661 tgttacaaaa aaacccttct tggtggatta gacaggttaa atatataaac aaacaaacaa
12721 aaattgctca aaaaagagga gaaaagctca agaggaaaag ctaaggactg gtaggaaaaa
12781 gctttactct ttcatgccat tttatttctt tttgattttt aaatcattca ttcaatagat
12841 accaccgtgt gacctataat tttgcaaatc tgttacctct gacatcaagt gtaattagct
12901 tttggagagt gggctgacat caagtgtaat tagcttttgg agagtgggtt ttgtccatta
12961 ttaataatta attaattaac atcaaacacg gcttctcatg ctatttctac ctcactttgg
13021 ttttggggtg ttcctgataa ttgtgcacac ctgagttcac agcttcacca cttgtccatt
13081 gcgttatttt ctttttcctt tataattctt tctttttcct tcataatttt caaaagaaaa
13141 cccaaagctc taaggtaaca aattaccaaa ttacatgaag atttggtttt tgtcttgcat
13201 ttttttcctt tatgtgacgc tggacctttt ctttacccaa ggatttttaa aactcagatt
13261 taaaacaagg ggttacttta catcctacta agaagtttaa gtaagtaagt ttcattctaa
13321 aatcagaggt aaatagagtg cataaataat tttgttttaa tctttttgtt tttcttttag
13381 acacattagc tctggagtga gtctgtcata atatttgaac aaaaattgag agctttattg
13441 ctgcatttta agcataatta atttggacat tatttcgtgt tgtgttcttt ataaccaccg
13501 agtattaaac tgtaaatcat aatgtaactg aagcataaac atcacatggc atgttttgtc
13561 attgttttca ggtactgagt tcttacttga gtatcataat atattgtgtt ttaacaccaa
13621 cactgtaaca tttacgaatt atttttttaa acttcagttt tactgcattt tcacaacata
13681 tcagacttca ccaaatatat gccttactat tgtattatag tactgcttta ctgtgtatct
13741 caataaagca cgcagttatg ttac
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