(last modified March 2, 1999)
Submitted to GenBank
LOCUS Dp427c 14069 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp427c (brain).
ACCESSION Dp427c
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 237 to 351)
AUTHORS Nudel,U., Zuk,D., Einat,P., Zeelon,E., Levy,Z., Neuman,S. and
Yaffe,D.
TITLE Duchenne muscular dystrophy gene product is not identical in muscle
and brain
JOURNAL Nature 337, 76-78 (1989)
REFERENCE 2 (bases 237 to 416)
AUTHORS Feener,C.A., Koenig,M. and Kunkel,L.M.
TITLE Alternative splicing of human dystrophin mRNA generates isoforms at
the carboxy terminus
JOURNAL Nature 338, 509-511 (1989)
MEDLINE 89181947
REFERENCE 3 (bases 1 to 351)
AUTHORS Hugnot,J.-P., Gilgenkrantz,K., Jeanpierre,M., Chelly,J.,
Kaplan,J.C. and Kahn,A.
TITLE Striking conservation of the brain-specific region of the
dystrophin gene
JOURNAL Mamm. Genome 4, 393-396 (1993)
MEDLINE 93364119
REFERENCE 4 (bases 1 to 14069)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
COMMENT Constructed consensus sequence of L01538, X15148 and M18533.
FEATURES Location/Qualifiers
source 1..14069
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
/tissue_type="brain"
5'UTR 1..344
misc_feature 345..353
/note="Region: dystrophin Dp427c unique N-terminus"
CDS 345..11378
/codon_start=1
/product="dystrophin Dp427c"
/translation="MEDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLD
LLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGL
IWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLA
LNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKK
SILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQ
GYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLD
RYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL
QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLK
ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVV
VDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW
LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK
NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTT
REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFA
IFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE
QLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT
AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF
SDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG
ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVE
HCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS
DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG
GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEA
KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHE
LLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQ
TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESL
TFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI
DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQL
NHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT
ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQ
KEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLE
YQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDST
RDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQK
LLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK
QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRD
ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF
RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC
AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLD
FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAK
YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQ
LSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLL
VEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAV
QAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPG
LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSL
LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEA
RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE
SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI
TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR
KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR
LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGG
DFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE
ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ
AEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS
PYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPN
KVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSL
SAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN
VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSI
QIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVE
YCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFW
PVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQH
YCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHE
HKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQL
HRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSP
PQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature 354..1040
/note="Region: Actin binding domain"
misc_feature 1077..9440
/note="Region: central rod domain"
misc_feature 1077..1301
/note="Region: hinge region 1"
misc_feature 1329..1661
/note="Region: repeat region 1"
misc_feature 1662..1988
/note="Region: repeat region 2"
misc_feature 1989..2321
/note="Region: repeat region 3"
misc_feature 2322..2471
/note="Region: hinge region 2"
misc_feature 2472..2804
/note="Region: repeat region 4"
misc_feature 2805..3122
/note="Region: repeat region 5"
misc_feature 3123..3455
/note="Region: repeat region 6"
misc_feature 3456..3782
/note="Region: repeat region 7"
misc_feature 3783..4109
/note="Region: repeat region 8"
misc_feature 4110..4421
/note="Region: repeat region 9"
misc_feature 4422..4709
/note="Region: repeat region 10"
misc_feature 4701..5024
/note="Region: repeat region 11"
misc_feature 5025..5348
/note="Region: repeat region 12"
misc_feature 5349..5654
/note="Region: repeat region 13"
misc_feature 5655..5942
/note="Region: repeat region 14"
misc_feature 5943..6239
/note="Region: repeat region 15"
misc_feature 6294..6623
/note="Region: repeat region 16"
misc_feature 6624..6944
/note="Region: repeat region 17"
misc_feature 6945..7274
/note="Region: repeat region 18"
misc_feature 7275..7589
/note="Region: repeat region 19"
misc_feature 7590..7730
/note="Region: hinge region 3"
misc_feature 7731..8051
/note="Region: repeat region 20"
misc_feature 8052..8378
/note="Region: repeat region 21"
misc_feature 8379..8726
/note="Region: repeat region 22"
misc_feature 8727..9113
/note="Region: repeat region 23"
misc_feature 9114..9440
/note="Region: repeat region 24"
misc_feature 9360..9656
/note="Region: hinge region 4"
misc_feature 9486..9596
/note="Region: WW-domain"
misc_feature 9558..10544
/note="dystroglycan binding site"
misc_feature 9618..10220
/note="Region: Cysteine-rich domain"
misc_feature 9708..9791
/note="Region: EF-hand 1"
misc_feature 9852..9938
/note="Region: EF-hand 2"
misc_feature 10218..11375
/note="Region: Carboxy-terminal region"
misc_feature 10239..10382
/note="Region: ZZ-domain"
misc_feature 10650..10802
/note="alpha1-syntrophin binding site"
misc_feature 10803..10925
/note="beta1-syntrophin binding site"
misc_feature 10803..10925
/note="Region: beta1-syntrophin binding site"
misc_feature 10992..11099
/note="Region: (Leu)6-heptad repeat"
3'UTR 11379..14069
polyA_signal 14047..14052
polyA_site 14069
BASE COUNT 4640 a 2807 c 3159 g 3463 t
ORIGIN
1 cgttaaatgc aaacgctgct ctggctcatg tgtttgctcc gaggtatagg ttttgttcga
61 ctgacgtatc agatagtcag agtggttacc acaccgacgt tgtagcagct gcataataaa
121 tgactgaaag aatcatgtta ggcatgccca cctaacctaa cttgaatcat gcgaaagggg
181 agctgttgga attcaaatag actttctggt tcccagcagt cggcagtaat agaatgcttt
241 caggaagatg acagaatcag gagaaagatg ctgttttgca ctatcttgat ttgttacagc
301 agccaactta ttggcatgat ggagtgacag gaaaaacagc tggcatggaa gatgaaagag
361 aagatgttca aaagaaaaca ttcacaaaat gggtaaatgc acaattttct aagtttggga
421 agcagcatat tgagaacctc ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc
481 tcgaaggcct gacagggcaa aaactgccaa aagaaaaagg atccacaaga gttcatgccc
541 tgaacaatgt caacaaggca ctgcgggttt tgcagaacaa taatgttgat ttagtgaata
601 ttggaagtac tgacatcgta gatggaaatc ataaactgac tcttggtttg atttggaata
661 taatcctcca ctggcaggtc aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa
721 ccaacagtga aaagattctc ctgagctggg tccgacaatc aactcgtaat tatccacagg
781 ttaatgtaat caacttcacc accagctggt ctgatggcct ggctttgaat gctctcatcc
841 atagtcatag gccagaccta tttgactgga atagtgtggt ttgccagcag tcagccacac
901 aacgactgga acatgcattc aacatcgcca gatatcaatt aggcatagag aaactactcg
961 atcctgaaga tgttgatacc acctatccag ataagaagtc catcttaatg tacatcacat
1021 cactcttcca agttttgcct caacaagtga gcattgaagc catccaggaa gtggaaatgt
1081 tgccaaggcc acctaaagtg actaaagaag aacattttca gttacatcat caaatgcact
1141 attctcaaca gatcacggtc agtctagcac agggatatga gagaacttct tcccctaagc
1201 ctcgattcaa gagctatgcc tacacacagg ctgcttatgt caccacctct gaccctacac
1261 ggagcccatt tccttcacag catttggaag ctcctgaaga caagtcattt ggcagttcat
1321 tgatggagag tgaagtaaac ctggaccgtt atcaaacagc tttagaagaa gtattatcgt
1381 ggcttctttc tgctgaggac acattgcaag cacaaggaga gatttctaat gatgtggaag
1441 tggtgaaaga ccagtttcat actcatgagg ggtacatgat ggatttgaca gcccatcagg
1501 gccgggttgg taatattcta caattgggaa gtaagctgat tggaacagga aaattatcag
1561 aagatgaaga aactgaagta caagagcaga tgaatctcct aaattcaaga tgggaatgcc
1621 tcagggtagc tagcatggaa aaacaaagca atttacatag agttttaatg gatctccaga
1681 atcagaaact gaaagagttg aatgactggc taacaaaaac agaagaaaga acaaggaaaa
1741 tggaggaaga gcctcttgga cctgatcttg aagacctaaa acgccaagta caacaacata
1801 aggtgcttca agaagatcta gaacaagaac aagtcagggt caattctctc actcacatgg
1861 tggtggtagt tgatgaatct agtggagatc acgcaactgc tgctttggaa gaacaactta
1921 aggtattggg agatcgatgg gcaaacatct gtagatggac agaagaccgc tgggttcttt
1981 tacaagacat ccttctcaaa tggcaacgtc ttactgaaga acagtgcctt tttagtgcat
2041 ggctttcaga aaaagaagat gcagtgaaca agattcacac aactggcttt aaagatcaaa
2101 atgaaatgtt atcaagtctt caaaaactgg ccgttttaaa agcggatcta gaaaagaaaa
2161 agcaatccat gggcaaactg tattcactca aacaagatct tctttcaaca ctgaagaata
2221 agtcagtgac ccagaagacg gaagcatggc tggataactt tgcccggtgt tgggataatt
2281 tagtccaaaa acttgaaaag agtacagcac agatttcaca ggctgtcacc accactcagc
2341 catcactaac acagacaact gtaatggaaa cagtaactac ggtgaccaca agggaacaga
2401 tcctggtaaa gcatgctcaa gaggaacttc caccaccacc tccccaaaag aagaggcaga
2461 ttactgtgga ttctgaaatt aggaaaaggt tggatgttga tataactgaa cttcacagct
2521 ggattactcg ctcagaagct gtgttgcaga gtcctgaatt tgcaatcttt cggaaggaag
2581 gcaacttctc agacttaaaa gaaaaagtca atgccataga gcgagaaaaa gctgagaagt
2641 tcagaaaact gcaagatgcc agcagatcag ctcaggccct ggtggaacag atggtgaatg
2701 agggtgttaa tgcagatagc atcaaacaag cctcagaaca actgaacagc cggtggatcg
2761 aattctgcca gttgctaagt gagagactta actggctgga gtatcagaac aacatcatcg
2821 ctttctataa tcagctacaa caattggagc agatgacaac tactgctgaa aactggttga
2881 aaatccaacc caccacccca tcagagccaa cagcaattaa aagtcagtta aaaatttgta
2941 aggatgaagt caaccggcta tcaggtcttc aacctcaaat tgaacgatta aaaattcaaa
3001 gcatagccct gaaagagaaa ggacaaggac ccatgttcct ggatgcagac tttgtggcct
3061 ttacaaatca ttttaagcaa gtcttttctg atgtgcaggc cagagagaaa gagctacaga
3121 caatttttga cactttgcca ccaatgcgct atcaggagac catgagtgcc atcaggacat
3181 gggtccagca gtcagaaacc aaactctcca tacctcaact tagtgtcacc gactatgaaa
3241 tcatggagca gagactcggg gaattgcagg ctttacaaag ttctctgcaa gagcaacaaa
3301 gtggcctata ctatctcagc accactgtga aagagatgtc gaagaaagcg ccctctgaaa
3361 ttagccggaa atatcaatca gaatttgaag aaattgaggg acgctggaag aagctctcct
3421 cccagctggt tgagcattgt caaaagctag aggagcaaat gaataaactc cgaaaaattc
3481 agaatcacat acaaaccctg aagaaatgga tggctgaagt tgatgttttt ctgaaggagg
3541 aatggcctgc ccttggggat tcagaaattc taaaaaagca gctgaaacag tgcagacttt
3601 tagtcagtga tattcagaca attcagccca gtctaaacag tgtcaatgaa ggtgggcaga
3661 agataaagaa tgaagcagag ccagagtttg cttcgagact tgagacagaa ctcaaagaac
3721 ttaacactca gtgggatcac atgtgccaac aggtctatgc cagaaaggag gccttgaagg
3781 gaggtttgga gaaaactgta agcctccaga aagatctatc agagatgcac gaatggatga
3841 cacaagctga agaagagtat cttgagagag attttgaata taaaactcca gatgaattac
3901 agaaagcagt tgaagagatg aagagagcta aagaagaggc ccaacaaaaa gaagcgaaag
3961 tgaaactcct tactgagtct gtaaatagtg tcatagctca agctccacct gtagcacaag
4021 aggccttaaa aaaggaactt gaaactctaa ccaccaacta ccagtggctc tgcactaggc
4081 tgaatgggaa atgcaagact ttggaagaag tttgggcatg ttggcatgag ttattgtcat
4141 acttggagaa agcaaacaag tggctaaatg aagtagaatt taaacttaaa accactgaaa
4201 acattcctgg cggagctgag gaaatctctg aggtgctaga ttcacttgaa aatttgatgc
4261 gacattcaga ggataaccca aatcagattc gcatattggc acagacccta acagatggcg
4321 gagtcatgga tgagctaatc aatgaggaac ttgagacatt taattctcgt tggagggaac
4381 tacatgaaga ggctgtaagg aggcaaaagt tgcttgaaca gagcatccag tctgcccagg
4441 agactgaaaa atccttacac ttaatccagg agtccctcac attcattgac aagcagttgg
4501 cagcttatat tgcagacaag gtggacgcag ctcaaatgcc tcaggaagcc cagaaaatcc
4561 aatctgattt gacaagtcat gagatcagtt tagaagaaat gaagaaacat aatcagggga
4621 aggaggctgc ccaaagagtc ctgtctcaga ttgatgttgc acagaaaaaa ttacaagatg
4681 tctccatgaa gtttcgatta ttccagaaac cagccaattt tgagcagcgt ctacaagaaa
4741 gtaagatgat tttagatgaa gtgaagatgc acttgcctgc attggaaaca aagagtgtgg
4801 aacaggaagt agtacagtca cagctaaatc attgtgtgaa cttgtataaa agtctgagtg
4861 aagtgaagtc tgaagtggaa atggtgataa agactggacg tcagattgta cagaaaaagc
4921 agacggaaaa tcccaaagaa cttgatgaaa gagtaacagc tttgaaattg cattataatg
4981 agctgggagc aaaggtaaca gaaagaaagc aacagttgga gaaatgcttg aaattgtccc
5041 gtaagatgcg aaaggaaatg aatgtcttga cagaatggct ggcagctaca gatatggaat
5101 tgacaaagag atcagcagtt gaaggaatgc ctagtaattt ggattctgaa gttgcctggg
5161 gaaaggctac tcaaaaagag attgagaaac agaaggtgca cctgaagagt atcacagagg
5221 taggagaggc cttgaaaaca gttttgggca agaaggagac gttggtggaa gataaactca
5281 gtcttctgaa tagtaactgg atagctgtca cctcccgagc agaagagtgg ttaaatcttt
5341 tgttggaata ccagaaacac atggaaactt ttgaccagaa tgtggaccac atcacaaagt
5401 ggatcattca ggctgacaca cttttggatg aatcagagaa aaagaaaccc cagcaaaaag
5461 aagacgtgct taagcgttta aaggcagaac tgaatgacat acgcccaaag gtggactcta
5521 cacgtgacca agcagcaaac ttgatggcaa accgcggtga ccactgcagg aaattagtag
5581 agccccaaat ctcagagctc aaccatcgat ttgcagccat ttcacacaga attaagactg
5641 gaaaggcctc cattcctttg aaggaattgg agcagtttaa ctcagatata caaaaattgc
5701 ttgaaccact ggaggctgaa attcagcagg gggtgaatct gaaagaggaa gacttcaata
5761 aagatatgaa tgaagacaat gagggtactg taaaagaatt gttgcaaaga ggagacaact
5821 tacaacaaag aatcacagat gagagaaagc gagaggaaat aaagataaaa cagcagctgt
5881 tacagacaaa acataatgct ctcaaggatt tgaggtctca aagaagaaaa aaggctctag
5941 aaatttctca tcagtggtat cagtacaaga ggcaggctga tgatctcctg aaatgcttgg
6001 atgacattga aaaaaaatta gccagcctac ctgagcccag agatgaaagg aaaataaagg
6061 aaattgatcg ggaattgcag aagaagaaag aggagctgaa tgcagtgcgt aggcaagctg
6121 agggcttgtc tgaggatggg gccgcaatgg cagtggagcc aactcagatc cagctcagca
6181 agcgctggcg ggaaattgag agcaaatttg ctcagtttcg aagactcaac tttgcacaaa
6241 ttcacactgt ccgtgaagaa acgatgatgg tgatgactga agacatgcct ttggaaattt
6301 cttatgtgcc ttctacttat ttgactgaaa tcactcatgt ctcacaagcc ctattagaag
6361 tggaacaact tctcaatgct cctgacctct gtgctaagga ctttgaagat ctctttaagc
6421 aagaggagtc tctgaagaat ataaaagata gtctacaaca aagctcaggt cggattgaca
6481 ttattcatag caagaagaca gcagcattgc aaagtgcaac gcctgtggaa agggtgaagc
6541 tacaggaagc tctctcccag cttgatttcc aatgggaaaa agttaacaaa atgtacaagg
6601 accgacaagg gcgatttgac agatctgttg agaaatggcg gcgttttcat tatgatataa
6661 agatatttaa tcagtggcta acagaagctg aacagtttct cagaaagaca caaattcctg
6721 agaattggga acatgctaaa tacaaatggt atcttaagga actccaggat ggcattgggc
6781 agcggcaaac tgttgtcaga acattgaatg caactgggga agaaataatt cagcaatcct
6841 caaaaacaga tgccagtatt ctacaggaaa aattgggaag cctgaatctg cggtggcagg
6901 aggtctgcaa acagctgtca gacagaaaaa agaggctaga agaacaaaag aatatcttgt
6961 cagaatttca aagagattta aatgaatttg ttttatggtt ggaggaagca gataacattg
7021 ctagtatccc acttgaacct ggaaaagagc agcaactaaa agaaaagctt gagcaagtca
7081 agttactggt ggaagagttg cccctgcgcc agggaattct caaacaatta aatgaaactg
7141 gaggacccgt gcttgtaagt gctcccataa gcccagaaga gcaagataaa cttgaaaata
7201 agctcaagca gacaaatctc cagtggataa aggtttccag agctttacct gagaaacaag
7261 gagaaattga agctcaaata aaagaccttg ggcagcttga aaaaaagctt gaagaccttg
7321 aagagcagtt aaatcatctg ctgctgtggt tatctcctat taggaatcag ttggaaattt
7381 ataaccaacc aaaccaagaa ggaccatttg acgttcagga aactgaaata gcagttcaag
7441 ctaaacaacc ggatgtggaa gagattttgt ctaaagggca gcatttgtac aaggaaaaac
7501 cagccactca gccagtgaag aggaagttag aagatctgag ctctgagtgg aaggcggtaa
7561 accgtttact tcaagagctg agggcaaagc agcctgacct agctcctgga ctgaccacta
7621 ttggagcctc tcctactcag actgttactc tggtgacaca acctgtggtt actaaggaaa
7681 ctgccatctc caaactagaa atgccatctt ccttgatgtt ggaggtacct gctctggcag
7741 atttcaaccg ggcttggaca gaacttaccg actggctttc tctgcttgat caagttataa
7801 aatcacagag ggtgatggtg ggtgaccttg aggatatcaa cgagatgatc atcaagcaga
7861 aggcaacaat gcaggatttg gaacagaggc gtccccagtt ggaagaactc attaccgctg
7921 cccaaaattt gaaaaacaag accagcaatc aagaggctag aacaatcatt acggatcgaa
7981 ttgaaagaat tcagaatcag tgggatgaag tacaagaaca ccttcagaac cggaggcaac
8041 agttgaatga aatgttaaag gattcaacac aatggctgga agctaaggaa gaagctgagc
8101 aggtcttagg acaggccaga gccaagcttg agtcatggaa ggagggtccc tatacagtag
8161 atgcaatcca aaagaaaatc acagaaacca agcagttggc caaagacctc cgccagtggc
8221 agacaaatgt agatgtggca aatgacttgg ccctgaaact tctccgggat tattctgcag
8281 atgataccag aaaagtccac atgataacag agaatatcaa tgcctcttgg agaagcattc
8341 ataaaagggt gagtgagcga gaggctgctt tggaagaaac tcatagatta ctgcaacagt
8401 tccccctgga cctggaaaag tttcttgcct ggcttacaga agctgaaaca actgccaatg
8461 tcctacagga tgctacccgt aaggaaaggc tcctagaaga ctccaaggga gtaaaagagc
8521 tgatgaaaca atggcaagac ctccaaggtg aaattgaagc tcacacagat gtttatcaca
8581 acctggatga aaacagccaa aaaatcctga gatccctgga aggttccgat gatgcagtcc
8641 tgttacaaag acgtttggat aacatgaact tcaagtggag tgaacttcgg aaaaagtctc
8701 tcaacattag gtcccatttg gaagccagtt ctgaccagtg gaagcgtctg cacctttctc
8761 tgcaggaact tctggtgtgg ctacagctga aagatgatga attaagccgg caggcaccta
8821 ttggaggcga ctttccagca gttcagaagc agaacgatgt acatagggcc ttcaagaggg
8881 aattgaaaac taaagaacct gtaatcatga gtactcttga gactgtacga atatttctga
8941 cagagcagcc tttggaagga ctagagaaac tctaccagga gcccagagag ctgcctcctg
9001 aggagagagc ccagaatgtc actcggcttc tacgaaagca ggctgaggag gtcaatactg
9061 agtgggaaaa attgaacctg cactccgctg actggcagag aaaaatagat gagacccttg
9121 aaagactcca ggaacttcaa gaggccacgg atgagctgga cctcaagctg cgccaagctg
9181 aggtgatcaa gggatcctgg cagcccgtgg gcgatctcct cattgactct ctccaagatc
9241 acctcgagaa agtcaaggca cttcgaggag aaattgcgcc tctgaaagag aacgtgagcc
9301 acgtcaatga ccttgctcgc cagcttacca ctttgggcat tcagctctca ccgtataacc
9361 tcagcactct ggaagacctg aacaccagat ggaagcttct gcaggtggcc gtcgaggacc
9421 gagtcaggca gctgcatgaa gcccacaggg actttggtcc agcatctcag cactttcttt
9481 ccacgtctgt ccagggtccc tgggagagag ccatctcgcc aaacaaagtg ccctactata
9541 tcaaccacga gactcaaaca acttgctggg accatcccaa aatgacagag ctctaccagt
9601 ctttagctga cctgaataat gtcagattct cagcttatag gactgccatg aaactccgaa
9661 gactgcagaa ggccctttgc ttggatctct tgagcctgtc agctgcatgt gatgccttgg
9721 accagcacaa cctcaagcaa aatgaccagc ccatggatat cctgcagatt attaattgtt
9781 tgaccactat ttatgaccgc ctggagcaag agcacaacaa tttggtcaac gtccctctct
9841 gcgtggatat gtgtctgaac tggctgctga atgtttatga tacgggacga acagggagga
9901 tccgtgtcct gtcttttaaa actggcatca tttccctgtg taaagcacat ttggaagaca
9961 agtacagata ccttttcaag caagtggcaa gttcaacagg attttgtgac cagcgcaggc
10021 tgggcctcct tctgcatgat tctatccaaa ttccaagaca gttgggtgaa gttgcatcct
10081 ttgggggcag taacattgag ccaagtgtcc ggagctgctt ccaatttgct aataataagc
10141 cagagatcga agcggccctc ttcctagact ggatgagact ggaaccccag tccatggtgt
10201 ggctgcccgt cctgcacaga gtggctgctg cagaaactgc caagcatcag gccaaatgta
10261 acatctgcaa agagtgtcca atcattggat tcaggtacag gagtctaaag cactttaatt
10321 atgacatctg ccaaagctgc tttttttctg gtcgagttgc aaaaggccat aaaatgcact
10381 atcccatggt ggaatattgc actccgacta catcaggaga agatgttcga gactttgcca
10441 aggtactaaa aaacaaattt cgaaccaaaa ggtattttgc gaagcatccc cgaatgggct
10501 acctgccagt gcagactgtc ttagaggggg acaacatgga aactcccgtt actctgatca
10561 acttctggcc agtagattct gcgcctgcct cgtcccctca gctttcacac gatgatactc
10621 attcacgcat tgaacattat gctagcaggc tagcagaaat ggaaaacagc aatggatctt
10681 atctaaatga tagcatctct cctaatgaga gcatagatga tgaacatttg ttaatccagc
10741 attactgcca aagtttgaac caggactccc ccctgagcca gcctcgtagt cctgcccaga
10801 tcttgatttc cttagagagt gaggaaagag gggagctaga gagaatccta gcagatcttg
10861 aggaagaaaa caggaatctg caagcagaat atgaccgtct aaagcagcag cacgaacata
10921 aaggcctgtc cccactgccg tcccctcctg aaatgatgcc cacctctccc cagagtcccc
10981 gggatgctga gctcattgct gaggccaagc tactgcgtca acacaaaggc cgcctggaag
11041 ccaggatgca aatcctggaa gaccacaata aacagctgga gtcacagtta cacaggctaa
11101 ggcagctgct ggagcaaccc caggcagagg ccaaagtgaa tggcacaacg gtgtcctctc
11161 cttctacctc tctacagagg tccgacagca gtcagcctat gctgctccga gtggttggca
11221 gtcaaacttc ggactccatg ggtgaggaag atcttctcag tcctccccag gacacaagca
11281 cagggttaga ggaggtgatg gagcaactca acaactcctt ccctagttca agaggaagaa
11341 atacccctgg aaagccaatg agagaggaca caatgtagga agtcttttcc acatggcaga
11401 tgatttgggc agagcgatgg agtccttagt atcagtcatg acagatgaag aaggagcaga
11461 ataaatgttt tacaactcct gattcccgca tggtttttat aatattcata caacaaagag
11521 gattagacag taagagttta caagaaataa atctatattt ttgtgaaggg tagtggtatt
11581 atactgtaga tttcagtagt ttctaagtct gttattgttt tgttaacaat ggcaggtttt
11641 acacgtctat gcaattgtac aaaaaagtta taagaaaact acatgtaaaa tcttgatagc
11701 taaataactt gccatttctt tatatggaac gcattttggg ttgtttaaaa atttataaca
11761 gttataaaga aagattgtaa actaaagtgt gctttataaa aaaaagttgt ttataaaaac
11821 ccctaaaaac aaaacaaaca cacacacaca cacatacaca cacacacaca aaactttgag
11881 gcagcgcatt gttttgcatc cttttggcgt gatatccata tgaaattcat ggctttttct
11941 ttttttgcat attaaagata agacttcctc taccaccaca ccaaatgact actacacact
12001 gctcatttga gaactgtcag ctgagtgggg caggcttgag ttttcatttc atatatctat
12061 atgtctataa gtatataaat actatagtta tatagataaa gagatacgaa tttctataga
12121 ctgacttttt ccatttttta aatgttcatg tcacatccta atagaaagaa attacttcta
12181 gtcagtcatc caggcttacc tgcttggtct agaatggatt tttcccggag ccggaagcca
12241 ggaggaaact acaccacact aaaacattgt ctacagctcc agatgtttct cattttaaac
12301 aactttccac tgacaacgaa agtaaagtaa agtattggat ttttttaaag ggaacatgtg
12361 aatgaataca caggacttat tatatcagag tgagtaatcg gttggttggt tgattgattg
12421 attgattgat acattcagct tcctgctgct agcaatgcca cgatttagat ttaatgatgc
12481 ttcagtggaa atcaatcaga aggtattctg accttgtgaa catcagaagg tattttttaa
12541 ctcccaagca gtagcaggac gatgataggg ctggagggct atggattccc agcccatccc
12601 tgtgaaggag taggccactc tttaagtgaa ggattggatg attgttcata atacataaag
12661 ttctctgtaa ttacaactaa attattatgc cctcttctca cagtcaaaag gaactgggtg
12721 gtttggtttt tgttgctttt ttagatttat tgtcccatgt gggatgagtt tttaaatgcc
12781 acaagacata atttaaaata aataaacttt gggaaaaggt gtaagacagt agccccatca
12841 catttgtgat actgacaggt atcaacccag aagcccatga actgtgtttc catcctttgc
12901 atttctctgc gagtagttcc acacaggttt gtaagtaagt aagaaagaag gcaaattgat
12961 tcaaatgtta caaaaaaacc cttcttggtg gattagacag gttaaatata taaacaaaca
13021 aacaaaaatt gctcaaaaaa gaggagaaaa gctcaagagg aaaagctaag gactggtagg
13081 aaaaagcttt actctttcat gccattttat ttctttttga tttttaaatc attcattcaa
13141 tagataccac cgtgtgacct ataattttgc aaatctgtta cctctgacat caagtgtaat
13201 tagcttttgg agagtgggct gacatcaagt gtaattagct tttggagagt gggttttgtc
13261 cattattaat aattaattaa ttaacatcaa acacggcttc tcatgctatt tctacctcac
13321 tttggttttg gggtgttcct gataattgtg cacacctgag ttcacagctt caccacttgt
13381 ccattgcgtt attttctttt tcctttataa ttctttcttt ttccttcata attttcaaaa
13441 gaaaacccaa agctctaagg taacaaatta ccaaattaca tgaagatttg gtttttgtct
13501 tgcatttttt tcctttatgt gacgctggac cttttcttta cccaaggatt tttaaaactc
13561 agatttaaaa caaggggtta ctttacatcc tactaagaag tttaagtaag taagtttcat
13621 tctaaaatca gaggtaaata gagtgcataa ataattttgt tttaatcttt ttgtttttct
13681 tttagacaca ttagctctgg agtgagtctg tcataatatt tgaacaaaaa ttgagagctt
13741 tattgctgca ttttaagcat aattaatttg gacattattt cgtgttgtgt tctttataac
13801 caccgagtat taaactgtaa atcataatgt aactgaagca taaacatcac atggcatgtt
13861 ttgtcattgt tttcaggtac tgagttctta cttgagtatc ataatatatt gtgttttaac
13921 accaacactg taacatttac gaattatttt tttaaacttc agttttactg cattttcaca
13981 acatatcaga cttcaccaaa tatatgcctt actattgtat tatagtactg ctttactgtg
14041 tatctcaata aagcacgcag ttatgttac
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