Leiden Muscular Dystrophy pages

Sarcoglycan homologies

(last modified on November 30, 2002)


Contents




SGCA / SGCE



SGCB / SGCG / SGCD / SGCZ


The human SGCD1 protein show a 95% amino acid identity with the hamster sequence, a weak homology with the N-terminus of beta-sarcoglycan and C. elegans clone F07H5.2. A weak homology was noted between the Cysteine-containing region of these sarcoglycans and the a so called "EGF-like cysteine containing repeat" of proteins like the LDL-receptor, laminin-A1 and fibrillin (McNally, consensus xCxCPxG[x]5-15C).

Fruitfly (D. melanogaster) and C. elegans both contain one gene which shows a strong similarity equally related to SGCG, SGCD and SGCZ.

  SGCB SGCG SGCD SGCZ
human SGCD 23 / 51 % 55 / 70 %    
mouse SGCZ 21 / 39 % 56 / 74 % 57 / 75 %  100

Legend: similarities of the human and mouse proteins with other sarcoglycan proteins (% identity / % similarity. For SGCD isoform-1 was taken. 


Alignment of sarcoglycan protein sequences


Not available yet


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