(last modified March 2, 1999)
Submitted to GenBank
LOCUS Dp427m 13993 bp mRNA PRI 20-JAN-1998
DEFINITION Human dystrophin cDNA isoform Dp427m (muscle).
ACCESSION Dp427m
KEYWORDS .
SOURCE human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1454 to 2082; 1707 to 3655)
AUTHORS Cross,G.S., Speer,A., Rosenthal,A., Forrest,S.M., Smith,T.J.,
Edwards,Y., Flint,T., Hill,D. and Davies,K.E.
TITLE Deletions of fetal and adult muscle cDNA in Duchenne and Becker
muscular dystrophy patients
JOURNAL EMBO J. 6, 3277-3283 (1987)
MEDLINE 88111512
REMARK GenBank M22818/X06178 with vector start (8 bp) and end (6 bp),
sequence error 2239^2240insGAT and probable polymorphism 592C/G.
GenBank M22819/X06179 with probable sequence errors 1453A>C,
2075G>A and 2080G>A and potential polymorphism 1914T/C.
REFERENCE 2 (bases 38 to 13993)
AUTHORS Kunkel,L.M., Feener,C., Monaco,A.P., Bertelson,C.J., Hoffman,E.P.
and Koenig,M.
TITLE Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and
preliminary genomic organization of the DMD gene in normal and
affected individuals
JOURNAL Cell 50, 509-517 (1987)
MEDLINE 87273512
REMARK GenBank M18533 with potential polymorphisms 4651A/T (+AluI) and
5774C/A. GenBank M20205 (with many differences, all typing errors)
REFERENCE 3 (bases 38 to 13993)
AUTHORS Koenig,M., Monaco,A.P. and Kunkel,L.M.
TITLE The complete sequence of dystrophin predicts a rod-shaped
cytoskeletal protein
JOURNAL Cell 53, 219-228 (1988)
REMARK corrects sequence conflict 43CA>TCC of GenBank M18533
REFERENCE 4 (bases 147 to 12592)
AUTHORS Rosenthal,A., Speer,A., Billwitz,H., Cross,G.S., Forrest,S.M. and
Davies,K.E.
TITLE Two human cDNA molecules coding for the Duchenne muscular dystrophy
(DMD) locus are highly homologous
JOURNAL Nucleic Acids Res. 17 (13), 5391 (1989)
MEDLINE 89345106
REMARK GenBank X14298 with conflicts 643A>C, 3833G>T, 4375A>T, 5221C>T and
5776A>C and possible polymorphisms at 1918T/G, 2111C/A and 2595C/G
REFERENCE 5 (sites)
AUTHORS Chelly,J., Gilgenkrantz,H., Lambert,M., Hamard,G., Chafey,P.,
Recan,D., Katz,P., de la Chapelle,A., Koenig,M., Ginjaar,I.B.,
Fardeau,M., Tome,F., Kahn,A. and Kaplan,J.-C.
TITLE Effect of dystrophin gene deletions on mRNA levels and processing
in Duchenne and Becker muscular dystrophies
JOURNAL Cell 63, 1239-1248 (1990)
MEDLINE 91084852
REMARK GenBank M63072, M63073, M63074 and M63075
REFERENCE 6 (bases 1 to 13993)
AUTHORS Bulman,D.E., Gangopadhyay,S.B., Bebchuck,K.G., Worton,R.G. and
Ray,P.N.
TITLE Point mutation in the human dystrophin gene: identification through
western blot analysis
JOURNAL Genomics 10 (2), 457-460 (1991)
MEDLINE 91301703
REMARK GenBank S43366
REFERENCE 7 (bases 1 to 13993)
AUTHORS Ehrenpreis,J., Hillers,M., Junkes,B., Pfordt,M., Schwinger,E. and
Vosberg,H.P.
TITLE Analysis of a dystrophin gene deletion by amplification of mRNA
isolated from DMD myotubes cultured in vitro
JOURNAL Genomics 10 (3), 551-557 (1991)
MEDLINE 91365360
REMARK GenBank S54699
REFERENCE 8 (sites)
AUTHORS Chelly,J., Gilgenkrantz,H., Hugnot,J.P., Hamard,G., Lambert,M.,
Recan,D., Akli,S., Cometto,M., Kahn,A. and Kaplan,J.C.
TITLE Illegitimate transcription. Application to the analysis of
truncated transcripts of the dystrophin gene in nonmuscle cultured
cells from Duchenne and Becker patients
JOURNAL J. Clin. Invest. 88 (4), 1161-1166 (1991)
MEDLINE 92012213
REMARK GenBank S60970, S60971, S60972 and S60973
REFERENCE 9 (bases 1 to 13993)
AUTHORS Roberts,R.G., Bobrow,M. and Bentley,D.R.
TITLE Point mutations in the dystrophin gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (6), 2331-2335 (1992)
MEDLINE 92196112
REMARK GenBank S88367, S88396 and S88398
REFERENCE 10 (bases 1 to 13993)
AUTHORS Narita,N., Nishio,H., Kitoh,Y., Ishikawa,Y., Ishikawa,Y.,
Minami,R., Nakamura,H. and Matsuo,M.
TITLE Insertion of a 5' truncated L1 element into the 3' end of exon 44
of the dystrophin gene resulted in skipping of the exon during
splicing in a case of Duchenne muscular dystrophy [see comments]
JOURNAL J. Clin. Invest. 91 (5), 1862-1867 (1993)
REMARK GenBank S60091
REFERENCE 11 (bases 1 to 13993)
AUTHORS den Dunnen,J.T.
TITLE Transcripts of the human dystrophin gene
JOURNAL Unpublished
REMARK More details regarding the nomenclature used, the annotations (e.g.
proper references), RFLP's and mutations found in DMD, BMD and
XLDCM patients, can be obtained from http://www.dmd.nl/
FEATURES Location/Qualifiers
source 1..13993
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp21.2"
/tissue_type="muscle"
5'UTR 1..244
245..11299
CDS 245..11302
/codon_start=1
/product="dystrophin Dp427m"
/translation="MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDL
QDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDG
NHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFT
TSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDV
DTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQ
QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSL
MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH
QGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN
SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE
EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLK
QDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVM
ETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEA
VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNA
DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ
PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAF
TNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDY
EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWK
KLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQL
KQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVY
ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAK
EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLE
EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNP
NQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS
LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEA
AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE
QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY
NELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE
VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAE
EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELND
IRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELE
QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER
KREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL
ASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE
IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQ
LLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI
PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNL
RWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKE
KLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVS
RALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD
VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA
KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT
ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK
NKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL
GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD
DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTA
NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD
DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL
SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ
EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD
ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL
TTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVD
MCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRL
GLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM
VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGH
KMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
PVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESID
DEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEY
DRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDH
NKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSM
GEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
misc_feature 245..277
/note="Region: dystrophin Dp427m unique N-terminus"
misc_feature 278..964
/note="Region: Actin binding domain"
mutation 338..5269
/note="minor alternatively spliced product of a genomic
deletion of exons 3-34 (joins exons 2 and 36, no frame
shift); determined on muscle RNA (M63074)"
/citation=[5]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
mutation 338..1204
/note="minor alternatively spliced product of a genomic
deletion of exons 3-7 (joins exons 2 and 10, no frame
shift); determined on muscle mRNA (S60972)"
/citation=[5]
/citation=[8]
/phenotype="Becker Muscular Dystrophy (DMD)"
mutation 338..5089
/note="deletion of exons 3-34, causing a frame shift;
determined on muscle RNA (M63073)"
/citation=[5]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
mutation 603..1847
/note="deletion of exons 6-13 (no frame shift); determined
on muscle RNA (M63075)"
/citation=[5]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
mutation 776..1847
/note="deletion of exons 7-13 causing a frame shift;
determined on lymphoblast and muscle mRNA (S60971)"
/citation=[8]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
1001..9364
misc_feature 1001..9364
/note="Region: central rod domain"
misc_feature 1001..1225
/note="Region: hinge region 1"
misc_feature 1253..1585
/note="Region: repeat region 1"
misc_feature 1586..1912
/note="Region: repeat region 2"
misc_feature 1913..2245
/note="Region: repeat region 3"
misc_feature 2246..2395
/note="Region: hinge region 2"
misc_feature 2396..2728
/note="Region: repeat region 4"
misc_feature 2729..3046
/note="Region: repeat region 5"
variation 2889
/note="creates BglII restriction site; in protein
Gly/Asp882"
/citation=[9]
/frequency="~0.25"
/replace="A"
misc_feature 3047..3379
/note="Region: repeat region 6"
misc_feature 3380..3706
/note="Region: repeat region 7"
misc_feature 3707..4033
/note="Region: repeat region 8"
mutation 3713
/note="point mutation causing translational stop; Glu1157X
(S43366)"
/citation=[6]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
/replace="T"
misc_feature 4034..4345
/note="Region: repeat region 9"
misc_feature 4346..4633
/note="Region: repeat region 10"
misc_feature 4625..4948
/note="Region: repeat region 11"
variation 4651
/note="creates AluI restriction site; in protein
Gln/Leu1469 (M18533)"
/citation=[2]
/replace="T"
misc_feature 4949..5272
/note="Region: repeat region 12"
misc_feature 5273..5578
/note="Region: repeat region 13"
variation 5478
/note="removes SacII restriction site; in protein
Arg/His1745 (X14298)"
/citation=[4]
/frequency="~0.40"
/replace="A"
misc_feature 5579..5866
/note="Region: repeat region 14"
variation 5774
/note="in protein Arg/Arg1844 (M18533)"
/citation=[2]
/replace="A"
mutation 5795
/note="point mutation causing translational stop; Gln1851X
(S88367)"
/citation=[9]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
/replace="T"
misc_feature 5867..6163
/note="Region: repeat region 15"
misc_feature 6218..6547
/note="Region: repeat region 16"
mutation 6535..6682
/note="insertion of a 5' truncated L1 element into the 3'
end of exon 44 resulting in skipping of the exon during
splicing and causing a frame shift; determined on RNA
(S60091)"
/citation=[10]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
mutation 6536..7157
/note="deletion of exons 44-47 causing a frame shift;
determined on lymphoblast mRNA (S60970)"
/citation=[8]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
misc_feature 6548..6868
/note="Region: repeat region 17"
misc_feature 6869..7198
/note="Region: repeat region 18"
mutation 7007..7553
/note="deletion of exons 47-50 causing a frame shift;
determined on RNA of cultured myotubes (S54699)"
/citation=[7]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
misc_feature 7199..7513
/note="Region: repeat region 19"
variation 7340
/note="removes MseI restriction site; in protein
Lys/Gln2366 (X14298)"
/citation=[4]
/frequency="~0.20"
/replace="A"
mutation 7445..7553
/note="deletion of exon 50 causing a frame shift;
determined on muscle RNA (M63072 and S60973)"
/citation=[5]
/citation=[8]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
misc_feature 7514..7654
/note="Region: hinge region 3"
misc_feature 7655..7975
/note="Region: repeat region 20"
misc_feature 7976..8302
/note="Region: repeat region 21"
misc_feature 8303..8650
/note="Region: repeat region 22"
misc_feature 8651..9037
/note="Region: repeat region 23"
misc_feature 9038..9364
/note="Region: repeat region 24"
misc_feature 9284..9580
/note="Region: hinge region 4"
misc_feature 9410..9520
/note="Region: WW-domain"
misc_feature 9482..10468
/note="dystroglycan binding site"
misc_feature 9542..10144
/note="Region: Cysteine-rich domain"
misc_feature 9632..9715
/note="Region: EF-hand 1"
misc_feature 9776..9862
/note="Region: EF-hand 2"
misc_feature 10142..11299
/note="Region: Carboxy-terminal region"
misc_feature 10163..10306
/note="Region: ZZ-domain"
misc_feature 10574..10726
/note="alpha1-syntrophin binding site"
mutation 10698
/note="deletion cuases frame shift and premature
translation termination (S88396, S88398)"
/citation=[9]
/phenotype="Duchenne Muscular Dystrophy (DMD)"
/replace="-"
misc_feature 10727..10849
/note="beta1-syntrophin binding site"
misc_feature 10727..10849
/note="Region: beta1-syntrophin binding site"
misc_feature 10916..11023
/note="Region: (Leu)6-heptad repeat"
3'UTR 11303..13993
polyA_signal 13971..13976
polyA_site 13993
BASE COUNT 4609 a 2790 c 3130 g 3464 t
ORIGIN
1 tcctggcatc agttactgtg ttgactcact cagtgttggg atcactcact ttccccctac
61 aggactcaga tctgggaggc aattaccttc ggagaaaaac gaataggaaa aactgaagtg
121 ttactttttt taaagctgct gaagtttgtt ggtttctcat tgtttttaag cctactggag
181 caataaagtt tgaagaactt ttaccaggtt ttttttatcg ctgccttgat atacactttt
241 caaaatgctt tggtgggaag aagtagagga ctgttatgaa agagaagatg ttcaaaagaa
301 aacattcaca aaatgggtaa atgcacaatt ttctaagttt gggaagcagc atattgagaa
361 cctcttcagt gacctacagg atgggaggcg cctcctagac ctcctcgaag gcctgacagg
421 gcaaaaactg ccaaaagaaa aaggatccac aagagttcat gccctgaaca atgtcaacaa
481 ggcactgcgg gttttgcaga acaataatgt tgatttagtg aatattggaa gtactgacat
541 cgtagatgga aatcataaac tgactcttgg tttgatttgg aatataatcc tccactggca
601 ggtcaaaaat gtaatgaaaa atatcatggc tggattgcaa caaaccaaca gtgaaaagat
661 tctcctgagc tgggtccgac aatcaactcg taattatcca caggttaatg taatcaactt
721 caccaccagc tggtctgatg gcctggcttt gaatgctctc atccatagtc ataggccaga
781 cctatttgac tggaatagtg tggtttgcca gcagtcagcc acacaacgac tggaacatgc
841 attcaacatc gccagatatc aattaggcat agagaaacta ctcgatcctg aagatgttga
901 taccacctat ccagataaga agtccatctt aatgtacatc acatcactct tccaagtttt
961 gcctcaacaa gtgagcattg aagccatcca ggaagtggaa atgttgccaa ggccacctaa
1021 agtgactaaa gaagaacatt ttcagttaca tcatcaaatg cactattctc aacagatcac
1081 ggtcagtcta gcacagggat atgagagaac ttcttcccct aagcctcgat tcaagagcta
1141 tgcctacaca caggctgctt atgtcaccac ctctgaccct acacggagcc catttccttc
1201 acagcatttg gaagctcctg aagacaagtc atttggcagt tcattgatgg agagtgaagt
1261 aaacctggac cgttatcaaa cagctttaga agaagtatta tcgtggcttc tttctgctga
1321 ggacacattg caagcacaag gagagatttc taatgatgtg gaagtggtga aagaccagtt
1381 tcatactcat gaggggtaca tgatggattt gacagcccat cagggccggg ttggtaatat
1441 tctacaattg ggaagtaagc tgattggaac aggaaaatta tcagaagatg aagaaactga
1501 agtacaagag cagatgaatc tcctaaattc aagatgggaa tgcctcaggg tagctagcat
1561 ggaaaaacaa agcaatttac atagagtttt aatggatctc cagaatcaga aactgaaaga
1621 gttgaatgac tggctaacaa aaacagaaga aagaacaagg aaaatggagg aagagcctct
1681 tggacctgat cttgaagacc taaaacgcca agtacaacaa cataaggtgc ttcaagaaga
1741 tctagaacaa gaacaagtca gggtcaattc tctcactcac atggtggtgg tagttgatga
1801 atctagtgga gatcacgcaa ctgctgcttt ggaagaacaa cttaaggtat tgggagatcg
1861 atgggcaaac atctgtagat ggacagaaga ccgctgggtt cttttacaag acatccttct
1921 caaatggcaa cgtcttactg aagaacagtg cctttttagt gcatggcttt cagaaaaaga
1981 agatgcagtg aacaagattc acacaactgg ctttaaagat caaaatgaaa tgttatcaag
2041 tcttcaaaaa ctggccgttt taaaagcgga tctagaaaag aaaaagcaat ccatgggcaa
2101 actgtattca ctcaaacaag atcttctttc aacactgaag aataagtcag tgacccagaa
2161 gacggaagca tggctggata actttgcccg gtgttgggat aatttagtcc aaaaacttga
2221 aaagagtaca gcacagattt cacaggctgt caccaccact cagccatcac taacacagac
2281 aactgtaatg gaaacagtaa ctacggtgac cacaagggaa cagatcctgg taaagcatgc
2341 tcaagaggaa cttccaccac cacctcccca aaagaagagg cagattactg tggattctga
2401 aattaggaaa aggttggatg ttgatataac tgaacttcac agctggatta ctcgctcaga
2461 agctgtgttg cagagtcctg aatttgcaat ctttcggaag gaaggcaact tctcagactt
2521 aaaagaaaaa gtcaatgcca tagagcgaga aaaagctgag aagttcagaa aactgcaaga
2581 tgccagcaga tcagctcagg ccctggtgga acagatggtg aatgagggtg ttaatgcaga
2641 tagcatcaaa caagcctcag aacaactgaa cagccggtgg atcgaattct gccagttgct
2701 aagtgagaga cttaactggc tggagtatca gaacaacatc atcgctttct ataatcagct
2761 acaacaattg gagcagatga caactactgc tgaaaactgg ttgaaaatcc aacccaccac
2821 cccatcagag ccaacagcaa ttaaaagtca gttaaaaatt tgtaaggatg aagtcaaccg
2881 gctatcaggt cttcaacctc aaattgaacg attaaaaatt caaagcatag ccctgaaaga
2941 gaaaggacaa ggacccatgt tcctggatgc agactttgtg gcctttacaa atcattttaa
3001 gcaagtcttt tctgatgtgc aggccagaga gaaagagcta cagacaattt ttgacacttt
3061 gccaccaatg cgctatcagg agaccatgag tgccatcagg acatgggtcc agcagtcaga
3121 aaccaaactc tccatacctc aacttagtgt caccgactat gaaatcatgg agcagagact
3181 cggggaattg caggctttac aaagttctct gcaagagcaa caaagtggcc tatactatct
3241 cagcaccact gtgaaagaga tgtcgaagaa agcgccctct gaaattagcc ggaaatatca
3301 atcagaattt gaagaaattg agggacgctg gaagaagctc tcctcccagc tggttgagca
3361 ttgtcaaaag ctagaggagc aaatgaataa actccgaaaa attcagaatc acatacaaac
3421 cctgaagaaa tggatggctg aagttgatgt ttttctgaag gaggaatggc ctgcccttgg
3481 ggattcagaa attctaaaaa agcagctgaa acagtgcaga cttttagtca gtgatattca
3541 gacaattcag cccagtctaa acagtgtcaa tgaaggtggg cagaagataa agaatgaagc
3601 agagccagag tttgcttcga gacttgagac agaactcaaa gaacttaaca ctcagtggga
3661 tcacatgtgc caacaggtct atgccagaaa ggaggccttg aagggaggtt tggagaaaac
3721 tgtaagcctc cagaaagatc tatcagagat gcacgaatgg atgacacaag ctgaagaaga
3781 gtatcttgag agagattttg aatataaaac tccagatgaa ttacagaaag cagttgaaga
3841 gatgaagaga gctaaagaag aggcccaaca aaaagaagcg aaagtgaaac tccttactga
3901 gtctgtaaat agtgtcatag ctcaagctcc acctgtagca caagaggcct taaaaaagga
3961 acttgaaact ctaaccacca actaccagtg gctctgcact aggctgaatg ggaaatgcaa
4021 gactttggaa gaagtttggg catgttggca tgagttattg tcatacttgg agaaagcaaa
4081 caagtggcta aatgaagtag aatttaaact taaaaccact gaaaacattc ctggcggagc
4141 tgaggaaatc tctgaggtgc tagattcact tgaaaatttg atgcgacatt cagaggataa
4201 cccaaatcag attcgcatat tggcacagac cctaacagat ggcggagtca tggatgagct
4261 aatcaatgag gaacttgaga catttaattc tcgttggagg gaactacatg aagaggctgt
4321 aaggaggcaa aagttgcttg aacagagcat ccagtctgcc caggagactg aaaaatcctt
4381 acacttaatc caggagtccc tcacattcat tgacaagcag ttggcagctt atattgcaga
4441 caaggtggac gcagctcaaa tgcctcagga agcccagaaa atccaatctg atttgacaag
4501 tcatgagatc agtttagaag aaatgaagaa acataatcag gggaaggagg ctgcccaaag
4561 agtcctgtct cagattgatg ttgcacagaa aaaattacaa gatgtctcca tgaagtttcg
4621 attattccag aaaccagcca attttgagca gcgtctacaa gaaagtaaga tgattttaga
4681 tgaagtgaag atgcacttgc ctgcattgga aacaaagagt gtggaacagg aagtagtaca
4741 gtcacagcta aatcattgtg tgaacttgta taaaagtctg agtgaagtga agtctgaagt
4801 ggaaatggtg ataaagactg gacgtcagat tgtacagaaa aagcagacgg aaaatcccaa
4861 agaacttgat gaaagagtaa cagctttgaa attgcattat aatgagctgg gagcaaaggt
4921 aacagaaaga aagcaacagt tggagaaatg cttgaaattg tcccgtaaga tgcgaaagga
4981 aatgaatgtc ttgacagaat ggctggcagc tacagatatg gaattgacaa agagatcagc
5041 agttgaagga atgcctagta atttggattc tgaagttgcc tggggaaagg ctactcaaaa
5101 agagattgag aaacagaagg tgcacctgaa gagtatcaca gaggtaggag aggccttgaa
5161 aacagttttg ggcaagaagg agacgttggt ggaagataaa ctcagtcttc tgaatagtaa
5221 ctggatagct gtcacctccc gagcagaaga gtggttaaat cttttgttgg aataccagaa
5281 acacatggaa acttttgacc agaatgtgga ccacatcaca aagtggatca ttcaggctga
5341 cacacttttg gatgaatcag agaaaaagaa accccagcaa aaagaagacg tgcttaagcg
5401 tttaaaggca gaactgaatg acatacgccc aaaggtggac tctacacgtg accaagcagc
5461 aaacttgatg gcaaaccgcg gtgaccactg caggaaatta gtagagcccc aaatctcaga
5521 gctcaaccat cgatttgcag ccatttcaca cagaattaag actggaaagg cctccattcc
5581 tttgaaggaa ttggagcagt ttaactcaga tatacaaaaa ttgcttgaac cactggaggc
5641 tgaaattcag cagggggtga atctgaaaga ggaagacttc aataaagata tgaatgaaga
5701 caatgagggt actgtaaaag aattgttgca aagaggagac aacttacaac aaagaatcac
5761 agatgagaga aagcgagagg aaataaagat aaaacagcag ctgttacaga caaaacataa
5821 tgctctcaag gatttgaggt ctcaaagaag aaaaaaggct ctagaaattt ctcatcagtg
5881 gtatcagtac aagaggcagg ctgatgatct cctgaaatgc ttggatgaca ttgaaaaaaa
5941 attagccagc ctacctgagc ccagagatga aaggaaaata aaggaaattg atcgggaatt
6001 gcagaagaag aaagaggagc tgaatgcagt gcgtaggcaa gctgagggct tgtctgagga
6061 tggggccgca atggcagtgg agccaactca gatccagctc agcaagcgct ggcgggaaat
6121 tgagagcaaa tttgctcagt ttcgaagact caactttgca caaattcaca ctgtccgtga
6181 agaaacgatg atggtgatga ctgaagacat gcctttggaa atttcttatg tgccttctac
6241 ttatttgact gaaatcactc atgtctcaca agccctatta gaagtggaac aacttctcaa
6301 tgctcctgac ctctgtgcta aggactttga agatctcttt aagcaagagg agtctctgaa
6361 gaatataaaa gatagtctac aacaaagctc aggtcggatt gacattattc atagcaagaa
6421 gacagcagca ttgcaaagtg caacgcctgt ggaaagggtg aagctacagg aagctctctc
6481 ccagcttgat ttccaatggg aaaaagttaa caaaatgtac aaggaccgac aagggcgatt
6541 tgacagatct gttgagaaat ggcggcgttt tcattatgat ataaagatat ttaatcagtg
6601 gctaacagaa gctgaacagt ttctcagaaa gacacaaatt cctgagaatt gggaacatgc
6661 taaatacaaa tggtatctta aggaactcca ggatggcatt gggcagcggc aaactgttgt
6721 cagaacattg aatgcaactg gggaagaaat aattcagcaa tcctcaaaaa cagatgccag
6781 tattctacag gaaaaattgg gaagcctgaa tctgcggtgg caggaggtct gcaaacagct
6841 gtcagacaga aaaaagaggc tagaagaaca aaagaatatc ttgtcagaat ttcaaagaga
6901 tttaaatgaa tttgttttat ggttggagga agcagataac attgctagta tcccacttga
6961 acctggaaaa gagcagcaac taaaagaaaa gcttgagcaa gtcaagttac tggtggaaga
7021 gttgcccctg cgccagggaa ttctcaaaca attaaatgaa actggaggac ccgtgcttgt
7081 aagtgctccc ataagcccag aagagcaaga taaacttgaa aataagctca agcagacaaa
7141 tctccagtgg ataaaggttt ccagagcttt acctgagaaa caaggagaaa ttgaagctca
7201 aataaaagac cttgggcagc ttgaaaaaaa gcttgaagac cttgaagagc agttaaatca
7261 tctgctgctg tggttatctc ctattaggaa tcagttggaa atttataacc aaccaaacca
7321 agaaggacca tttgacgttc aggaaactga aatagcagtt caagctaaac aaccggatgt
7381 ggaagagatt ttgtctaaag ggcagcattt gtacaaggaa aaaccagcca ctcagccagt
7441 gaagaggaag ttagaagatc tgagctctga gtggaaggcg gtaaaccgtt tacttcaaga
7501 gctgagggca aagcagcctg acctagctcc tggactgacc actattggag cctctcctac
7561 tcagactgtt actctggtga cacaacctgt ggttactaag gaaactgcca tctccaaact
7621 agaaatgcca tcttccttga tgttggaggt acctgctctg gcagatttca accgggcttg
7681 gacagaactt accgactggc tttctctgct tgatcaagtt ataaaatcac agagggtgat
7741 ggtgggtgac cttgaggata tcaacgagat gatcatcaag cagaaggcaa caatgcagga
7801 tttggaacag aggcgtcccc agttggaaga actcattacc gctgcccaaa atttgaaaaa
7861 caagaccagc aatcaagagg ctagaacaat cattacggat cgaattgaaa gaattcagaa
7921 tcagtgggat gaagtacaag aacaccttca gaaccggagg caacagttga atgaaatgtt
7981 aaaggattca acacaatggc tggaagctaa ggaagaagct gagcaggtct taggacaggc
8041 cagagccaag cttgagtcat ggaaggaggg tccctataca gtagatgcaa tccaaaagaa
8101 aatcacagaa accaagcagt tggccaaaga cctccgccag tggcagacaa atgtagatgt
8161 ggcaaatgac ttggccctga aacttctccg ggattattct gcagatgata ccagaaaagt
8221 ccacatgata acagagaata tcaatgcctc ttggagaagc attcataaaa gggtgagtga
8281 gcgagaggct gctttggaag aaactcatag attactgcaa cagttccccc tggacctgga
8341 aaagtttctt gcctggctta cagaagctga aacaactgcc aatgtcctac aggatgctac
8401 ccgtaaggaa aggctcctag aagactccaa gggagtaaaa gagctgatga aacaatggca
8461 agacctccaa ggtgaaattg aagctcacac agatgtttat cacaacctgg atgaaaacag
8521 ccaaaaaatc ctgagatccc tggaaggttc cgatgatgca gtcctgttac aaagacgttt
8581 ggataacatg aacttcaagt ggagtgaact tcggaaaaag tctctcaaca ttaggtccca
8641 tttggaagcc agttctgacc agtggaagcg tctgcacctt tctctgcagg aacttctggt
8701 gtggctacag ctgaaagatg atgaattaag ccggcaggca cctattggag gcgactttcc
8761 agcagttcag aagcagaacg atgtacatag ggccttcaag agggaattga aaactaaaga
8821 acctgtaatc atgagtactc ttgagactgt acgaatattt ctgacagagc agcctttgga
8881 aggactagag aaactctacc aggagcccag agagctgcct cctgaggaga gagcccagaa
8941 tgtcactcgg cttctacgaa agcaggctga ggaggtcaat actgagtggg aaaaattgaa
9001 cctgcactcc gctgactggc agagaaaaat agatgagacc cttgaaagac tccaggaact
9061 tcaagaggcc acggatgagc tggacctcaa gctgcgccaa gctgaggtga tcaagggatc
9121 ctggcagccc gtgggcgatc tcctcattga ctctctccaa gatcacctcg agaaagtcaa
9181 ggcacttcga ggagaaattg cgcctctgaa agagaacgtg agccacgtca atgaccttgc
9241 tcgccagctt accactttgg gcattcagct ctcaccgtat aacctcagca ctctggaaga
9301 cctgaacacc agatggaagc ttctgcaggt ggccgtcgag gaccgagtca ggcagctgca
9361 tgaagcccac agggactttg gtccagcatc tcagcacttt ctttccacgt ctgtccaggg
9421 tccctgggag agagccatct cgccaaacaa agtgccctac tatatcaacc acgagactca
9481 aacaacttgc tgggaccatc ccaaaatgac agagctctac cagtctttag ctgacctgaa
9541 taatgtcaga ttctcagctt ataggactgc catgaaactc cgaagactgc agaaggccct
9601 ttgcttggat ctcttgagcc tgtcagctgc atgtgatgcc ttggaccagc acaacctcaa
9661 gcaaaatgac cagcccatgg atatcctgca gattattaat tgtttgacca ctatttatga
9721 ccgcctggag caagagcaca acaatttggt caacgtccct ctctgcgtgg atatgtgtct
9781 gaactggctg ctgaatgttt atgatacggg acgaacaggg aggatccgtg tcctgtcttt
9841 taaaactggc atcatttccc tgtgtaaagc acatttggaa gacaagtaca gatacctttt
9901 caagcaagtg gcaagttcaa caggattttg tgaccagcgc aggctgggcc tccttctgca
9961 tgattctatc caaattccaa gacagttggg tgaagttgca tcctttgggg gcagtaacat
10021 tgagccaagt gtccggagct gcttccaatt tgctaataat aagccagaga tcgaagcggc
10081 cctcttccta gactggatga gactggaacc ccagtccatg gtgtggctgc ccgtcctgca
10141 cagagtggct gctgcagaaa ctgccaagca tcaggccaaa tgtaacatct gcaaagagtg
10201 tccaatcatt ggattcaggt acaggagtct aaagcacttt aattatgaca tctgccaaag
10261 ctgctttttt tctggtcgag ttgcaaaagg ccataaaatg cactatccca tggtggaata
10321 ttgcactccg actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa
10381 atttcgaacc aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac
10441 tgtcttagag ggggacaaca tggaaactcc cgttactctg atcaacttct ggccagtaga
10501 ttctgcgcct gcctcgtccc ctcagctttc acacgatgat actcattcac gcattgaaca
10561 ttatgctagc aggctagcag aaatggaaaa cagcaatgga tcttatctaa atgatagcat
10621 ctctcctaat gagagcatag atgatgaaca tttgttaatc cagcattact gccaaagttt
10681 gaaccaggac tcccccctga gccagcctcg tagtcctgcc cagatcttga tttccttaga
10741 gagtgaggaa agaggggagc tagagagaat cctagcagat cttgaggaag aaaacaggaa
10801 tctgcaagca gaatatgacc gtctaaagca gcagcacgaa cataaaggcc tgtccccact
10861 gccgtcccct cctgaaatga tgcccacctc tccccagagt ccccgggatg ctgagctcat
10921 tgctgaggcc aagctactgc gtcaacacaa aggccgcctg gaagccagga tgcaaatcct
10981 ggaagaccac aataaacagc tggagtcaca gttacacagg ctaaggcagc tgctggagca
11041 accccaggca gaggccaaag tgaatggcac aacggtgtcc tctccttcta cctctctaca
11101 gaggtccgac agcagtcagc ctatgctgct ccgagtggtt ggcagtcaaa cttcggactc
11161 catgggtgag gaagatcttc tcagtcctcc ccaggacaca agcacagggt tagaggaggt
11221 gatggagcaa ctcaacaact ccttccctag ttcaagagga agaaataccc ctggaaagcc
11281 aatgagagag gacacaatgt aggaagtctt ttccacatgg cagatgattt gggcagagcg
11341 atggagtcct tagtatcagt catgacagat gaagaaggag cagaataaat gttttacaac
11401 tcctgattcc cgcatggttt ttataatatt catacaacaa agaggattag acagtaagag
11461 tttacaagaa ataaatctat atttttgtga agggtagtgg tattatactg tagatttcag
11521 tagtttctaa gtctgttatt gttttgttaa caatggcagg ttttacacgt ctatgcaatt
11581 gtacaaaaaa gttataagaa aactacatgt aaaatcttga tagctaaata acttgccatt
11641 tctttatatg gaacgcattt tgggttgttt aaaaatttat aacagttata aagaaagatt
11701 gtaaactaaa gtgtgcttta taaaaaaaag ttgtttataa aaacccctaa aaacaaaaca
11761 aacacacaca cacacacata cacacacaca cacaaaactt tgaggcagcg cattgttttg
11821 catccttttg gcgtgatatc catatgaaat tcatggcttt ttcttttttt gcatattaaa
11881 gataagactt cctctaccac cacaccaaat gactactaca cactgctcat ttgagaactg
11941 tcagctgagt ggggcaggct tgagttttca tttcatatat ctatatgtct ataagtatat
12001 aaatactata gttatataga taaagagata cgaatttcta tagactgact ttttccattt
12061 tttaaatgtt catgtcacat cctaatagaa agaaattact tctagtcagt catccaggct
12121 tacctgcttg gtctagaatg gatttttccc ggagccggaa gccaggagga aactacacca
12181 cactaaaaca ttgtctacag ctccagatgt ttctcatttt aaacaacttt ccactgacaa
12241 cgaaagtaaa gtaaagtatt ggattttttt aaagggaaca tgtgaatgaa tacacaggac
12301 ttattatatc agagtgagta atcggttggt tggttgattg attgattgat tgatacattc
12361 agcttcctgc tgctagcaat gccacgattt agatttaatg atgcttcagt ggaaatcaat
12421 cagaaggtat tctgaccttg tgaacatcag aaggtatttt ttaactccca agcagtagca
12481 ggacgatgat agggctggag ggctatggat tcccagccca tccctgtgaa ggagtaggcc
12541 actctttaag tgaaggattg gatgattgtt cataatacat aaagttctct gtaattacaa
12601 ctaaattatt atgccctctt ctcacagtca aaaggaactg ggtggtttgg tttttgttgc
12661 ttttttagat ttattgtccc atgtgggatg agtttttaaa tgccacaaga cataatttaa
12721 aataaataaa ctttgggaaa aggtgtaaga cagtagcccc atcacatttg tgatactgac
12781 aggtatcaac ccagaagccc atgaactgtg tttccatcct ttgcatttct ctgcgagtag
12841 ttccacacag gtttgtaagt aagtaagaaa gaaggcaaat tgattcaaat gttacaaaaa
12901 aacccttctt ggtggattag acaggttaaa tatataaaca aacaaacaaa aattgctcaa
12961 aaaagaggag aaaagctcaa gaggaaaagc taaggactgg taggaaaaag ctttactctt
13021 tcatgccatt ttatttcttt ttgattttta aatcattcat tcaatagata ccaccgtgtg
13081 acctataatt ttgcaaatct gttacctctg acatcaagtg taattagctt ttggagagtg
13141 ggctgacatc aagtgtaatt agcttttgga gagtgggttt tgtccattat taataattaa
13201 ttaattaaca tcaaacacgg cttctcatgc tatttctacc tcactttggt tttggggtgt
13261 tcctgataat tgtgcacacc tgagttcaca gcttcaccac ttgtccattg cgttattttc
13321 tttttccttt ataattcttt ctttttcctt cataattttc aaaagaaaac ccaaagctct
13381 aaggtaacaa attaccaaat tacatgaaga tttggttttt gtcttgcatt tttttccttt
13441 atgtgacgct ggaccttttc tttacccaag gatttttaaa actcagattt aaaacaaggg
13501 gttactttac atcctactaa gaagtttaag taagtaagtt tcattctaaa atcagaggta
13561 aatagagtgc ataaataatt ttgttttaat ctttttgttt ttcttttaga cacattagct
13621 ctggagtgag tctgtcataa tatttgaaca aaaattgaga gctttattgc tgcattttaa
13681 gcataattaa tttggacatt atttcgtgtt gtgttcttta taaccaccga gtattaaact
13741 gtaaatcata atgtaactga agcataaaca tcacatggca tgttttgtca ttgttttcag
13801 gtactgagtt cttacttgag tatcataata tattgtgttt taacaccaac actgtaacat
13861 ttacgaatta tttttttaaa cttcagtttt actgcatttt cacaacatat cagacttcac
13921 caaatatatg ccttactatt gtattatagt actgctttac tgtgtatctc aataaagcac
13981 gcagttatgt tac
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