Peter-Bram 't Hoen                                                 

Research interests        Short vita        Research Focus        Other academic activities    Funding     Publications        Talks        Links        Contact

Research interests

Short vita

Born

  17th of January, 1975 in Hilversum, the Netherlands

Education

2002:                Ph.D. Degree in Natural Sciences from Leiden University . Title of thesis: Modulating the activity of biotransformation enzymes. Studies with antisense oligonucleotides and enzyme inhibitors.

1997:                Master of Science Degrees in Biochemistry and Pharmacochemistry from the Vrije Universiteit, Amsterdam , The Netherlands, both with honors

1997:                Practical Training at the Department of Pulmonary Medicine, University of California at Davis

1992-1997:        Chemistry and Pharmacochemistry studies at the Vrije Universiteit, Amsterdam , The Netherlands

1992:                Graduation from the Municipal Gymnasium, Hilversum , The Netherlands

  Jobs

2010                Assistant professor Center for Human and Clinical Genetics (LUMC), leading research group of 2 postdocs, 3 PhD students, 4 technicians.

2002-2009       Post-doctoral researcher in the group of dr. J.T. den Dunnen and prof.dr. G.J.B. van Ommen in the Center for Human and Clinical Genetics (LUMC). Project: "Unraveling the molecular mechanisms of neuromuscular disorders".

   

Research Focus  

Since 8 years, I have been working on the unravelling of the molecular mechanisms underlying neuromuscular disorders such as Duchenne Muscular Dystrophy, and the development of new molecular therapies for those. For this, I developed and applied high-throughput techniques such as microarrays, high-throughput sequencing and mass spectrometry-based proteomics. Although I was trained as a molecular biologist, I acquired bioinformatics and programming (R) skills and have become proficient in data analysis, data integration and statistics over the past few years. My main incentive is to make optimal use of available data to improve our understanding of biology in general and muscle biology in particular, and to translate this into clinically relevant applications. To do so, I lead a multidisciplinary team of researchers (molecular biologists and bioinformaticians) working on skeletal and cardiomyocyte differentiation and new molecular therapies for Duchenne muscular dystrophy and other muscular dystrophies. Within these lines I focus on and antisense and RNAi technology, miRNA biology, (cross-species) data integration, and analysis of biological networks.

 

Other academic activities

  • Co-promoter of 4 Ph.D. students

  •             -Rolf Turk (thesis completed: 2006)

  •             -Matt Hestand (thesis completed: 2010)

  • Co-organizer workshop on microarray meta-analysis in Berlin (August 2008).

  • Organization and teaching in several post-doctorate and post-HBO expert courses on microarray and next generation sequencing data analysis (amongst the first organized on these topics nationally and internationally).

  • Associate editor BMC Genomics

  • Teaching of “Microarray analysis using R” module at the Hogeschool Leiden (2006, 2007, 2008)

  • Teaching of workgroups on hereditary diseases to medicine students.

  • I was one of the founders of GeNeYouS (Genomics Network for Young Scientists) in 2003.

 

Funding

Ongoing research support (main applicant or workpackage leader)

  • EU-FP7 Integrated project “BIO-NMD” (workpackage leader “protein biomarkers”) (2009-2012)

  • Duchenne Parent Project “Team up TGF-β/myostatin antagonists and antisense-mediated exon skipping as a therapeutic approach for DMD” (2009-2011)

  • EU FP7 Integrated project “ENGAGE” (workpackage leader “Novel phenotypes”)  (2008-2013)

  • IOP Genomics grant “Towards broad clinical and technological application of gene expression engineering by exon skipping” (main applicant and project coordinator) (2007-2011)

Ongoing research support (co-applicant):

  • ZON-MW Pilotprogramma Translationeel Onderzoek (coordinator A.M. Aartsma-Rus) (2009-2011)

 

Completed research support

  • EU FP6 Integrated project “Heart Repair” (coordinator prof.dr. A.F. Moorman) (2006-2010)

  • Duchenne Parent Project “Integration of two promising therapeutic approaches for DMD: antisense oligonucleotide-mediated gene correction and myostatin inhibition” (2007-2009)

  • NWO VENI grant “Unraveling transcriptional networks in myogenesis” (2005-2007)

  • Center for Biomedical Genetics “A (r)evolutionary view on myogenesis - computational and experimental identification and functional validation of conserved regulatory elements in promoter regions” (2005-2009)

  • Prinses Beatrix Fonds “Developing mass spectrometry-based protein profiling for the diagnosis of neuromuscular disorders” (2005-2007) – 120 k€

  • Prinses Beatrix Fonds “Evaluation of the specificity and safety of therapeutic antisense oligonucleotides for Duchenne muscular dystrophy by microarray expression profiling” (2003-2005)

 

Publications

Invited lectures

Links

Center for Human and Clinical Genetics

Leiden Genome Technology Center

 

 

Address

Center for Human and Clinical Genetics

Leiden University Medical Center

Postzone S-04-P 

PO Box 9600

2300 RC Leiden

Netherlands

Phone: +31 71 526 9421

Fax:     +31 71 526 8285

Email:  p.a.c.hoen@Lumc.nl

Peter-Bram 't Hoen - Last updated: August 20th, 2010